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Table 1 MicroRNAs found significantly up-regulated in MCF7 cells exposed to hypoxia by analysis of microRNA-seq data

From: Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia

MicroRNAs significantly up-regulated in hypoxia at 16, 32 and 48 h (adj.p-val ≤ 0.05)

microRNAs

FC H16h

adj.p-val

FC H32h

adj.p-val

FC H48h

adj.p-val

hsa-miR-210-3p

3.24

0.0001

4.03

5.46e-07

3.96

8.41e-07

MicroRNAs significantly up-regulated in hypoxia at 32 and 48 h (adj.p-val ≤ 0.05)

microRNAs

FC H16h

adj.p-val

FC H32h

adj.p-val

FC H48h

adj.p-val

hsa-miR-1

1.86

0.4806

2.25

0.026223

3.12

0.000682

hsa-miR-106b-3p

1.10

0.9629

2.15

0.029336

1.94

0.048003

hsa-miR-1246

1.53

0.9046

5.08

0.000085

3.87

0.001346

hsa-miR-1269a

1.18

0.9399

2.43

0.005459

1.94

0.033244

hsa-miR-140-3p

1.11

0.9629

2.21

0.016949

2.01

0.027275

hsa-miR-141-5p

1.26

0.9046

1.78

0.049237

1.93

0.018787

hsa-miR-143-3p

1.82

0.2553

2.80

0.000136

1.90

0.021242

hsa-miR-151a-3p

1.35

0.9046

2.47

0.014476

2.34

0.016879

hsa-miR-181c-3p

1.12

0.9629

1.89

0.038509

1.84

0.035990

hsa-miR-192-5p

1.33

0.8665

2.14

0.009894

2.24

0.003741

hsa-miR-194-5p

1.09

0.9629

1.96

0.042635

2.28

0.008532

hsa-miR-195-3p

1.18

0.9555

2.49

0.007142

2.29

0.012846

hsa-miR-203a

1.21

0.9242

1.93

0.039759

1.93

0.030635

hsa-miR-215-5p

1.28

0.9046

2.92

0.001669

2.23

0.017671

hsa-miR-27a-5p

1.22

0.9046

1.90

0.026536

2.19

0.003759

hsa-miR-28-3p

0.97

0.9774

2.15

0.021442

2.04

0.025454

hsa-miR-3065-3p

1.27

0.9046

2.13

0.017787

2.67

0.000890

hsa-miR-30d-5p

1.24

0.9046

2.38

0.005459

3.31

0.000050

hsa-miR-30d-3p

1.43

0.8010

2.04

0.018042

1.80

0.041199

hsa-miR-30e-3p

1.26

0.9046

2.00

0.033309

2.35

0.005147

hsa-miR-3140-3p

1.13

0.9629

2.17

0.049237

2.31

0.025454

hsa-miR-3158-3p

2.19

0.0594

3.29

0.000032

2.65

0.000730

hsa-miR-338-5p

1.15

0.9604

2.11

0.018185

2.72

0.000672

hsa-miR-33b-5p

1.27

0.9046

2.87

0.000509

1.97

0.025454

hsa-miR-203b-3p

1.18

0.9555

2.11

0.047389

2.26

0.023495

hsa-miR-3619-3p

1.30

0.9242

3.11

0.004682

4.15

0.000159

hsa-miR-3677-3p

1.77

0.6186

2.94

0.002596

2.73

0.003759

hsa-miR-378c

1.02

0.9835

2.11

0.020104

1.88

0.040362

hsa-miR-378d

1.04

0.9629

2.39

0.013088

2.08

0.029016

hsa-miR-378i

1.38

0.8770

2.63

0.003952

2.69

0.002146

hsa-miR-3913-5p

1.06

0.9629

1.91

0.041667

2.26

0.006343

hsa-miR-3928-3p

1.22

0.9250

2.28

0.023169

2.12

0.030094

hsa-miR-4504

2.14

0.4257

2.97

0.006637

2.55

0.019065

hsa-miR-4746-5p

1.37

0.8665

2.13

0.018185

2.17

0.011517

hsa-miR-4760-5p

1.82

0.2984

2.04

0.017700

1.80

0.040620

hsa-miR-548a-3p

1.12

0.9629

2.55

0.032600

2.33

0.046620

hsa-miR-627-5p

1.44

0.8474

2.72

0.002857

2.29

0.011721

hsa-miR-92b-3p

1.19

0.9242

1.95

0.032600

2.22

0.006343

hsa-miR-942-5p

1.25

0.9046

2.08

0.016836

2.16

0.007682

hsa-miR-99b-5p

1.15

0.9629

2.39

0.018617

3.09

0.001097

MicroRNAs significantly up-regulated in hypoxia by QPCR †

microRNAs

FC H16h

adj.p-val

FC H32h

adj.p-val

FC H48h

adj.p-val

hsa-miR-24-2-5p

1.08

≥ 0.05

1.65

≤ 0.05

1.81

≤ 0.05

hsa-miR-27a-3p

1.93

≤ 0.05

2.84

≤ 0.05

2.02

≤ 0.05

hsa-miR-30b-3p

1.58

≥ 0.05

2.10

≤ 0.05

2.40

≤ 0.05

hsa-miR-30b-5p

1.20

≥ 0.05

2.23

≤ 0.05

1.81

≤ 0.05

  1. MicroRNAs in each section of the table are arranged in numerical order for ease of reading. Fold-change in linear scale (FC) and adjusted p value (adj.p-val) are shown for each microRNA at each hypoxia time. MicroRNAs which regulation by hypoxia has not been reported before are highlighted in bold. Last section shows microRNAs for which sequencing data did not produce significant results but were validated as up-regulated by qPCR (†).
  2. Hsa-miR-27a-3p was also found significantly up-regulated across the hypoxia time course in Agilent microarray data.
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Molecular Cancer

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