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Table 2 MicroRNAs found significantly down-regulated in MCF7 cells exposed to hypoxia by analysis of microRNA-seq data

From: Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia

MicroRNAs significantly down-regulated in hypoxia at 16,32 and 48 h (adj.p-val ≤ 0.05)

miRNAs

FC H16h

adj.p-val

FC H32h

adj.p-val

FC H48h

adj.p-val

hsa-miR-145-3p

0.16

5.60E-06

0.13

1.23E-07

0.10

1.16E-08

hsa-miR-222-5p

0.41

0.02943717

0.34

0.000541974

0.30

7.58E-05

hsa-miR-4521

0.16

2.29E-07

0.09

9.76E-12

0.09

7.42E-12

MicroRNAs significantly down-regulated in hypoxia at 16 and 32 h (adj.p-val ≤ 0.05)

miRNAs

FC H16h

adj.p-val

FC H32h

adj.p-val

FC H48h

adj.p-val

hsa-miR-29b-1-5p

0.41

0.02943717

0.53

0.049237065

0.64

0.160459153

MicroRNAs significantly down-regulated in hypoxia at 32 and 48 h (adj.p-val ≤ 0.05)

miRNAs

FC H16h

adj.p-val

FC H32h

adj.p-val

FC H48h

adj.p-val

hsa-let-7f-1-3p

0.58

0.618581404

0.37

0.003952372

0.46

0.02280333

hsa-miR-1260a

0.59

0.676561681

0.25

0.000224356

0.45

0.027900682

hsa-miR-1260b

0.52

0.480646057

0.19

1.21E-05

0.38

0.008394683

hsa-miR-1275

0.98

0.983716794

0.46

0.038509311

0.25

0.000158578

hsa-miR-15b-3p

0.92

0.962873516

0.32

0.003952372

0.36

0.007476629

hsa-miR-19a-3p

1.59

0.866491946

0.37

0.036219879

0.37

0.025453723

hsa-miR-19b-3p

1.55

0.866491946

0.33

0.018184509

0.34

0.016879484

hsa-miR-19b-1-5p

0.53

0.472759683

0.33

0.002596151

0.31

0.000890148

hsa-miR-22-3p

1.39

0.904640745

0.41

0.039758527

0.40

0.026856552

hsa-miR-221-5p

0.82

0.904640745

0.54

0.041249481

0.36

0.000264743

hsa-miR-23a-5p

0.35

0.225229269

0.30

0.016836038

0.16

0.000197073

hsa-miR-23b-5p

0.46

0.059350069

0.43

0.003952372

0.43

0.002649597

hsa-miR-296-3p

0.46

0.298355571

0.34

0.003952372

0.21

1.55E-05

hsa-miR-32-3p

0.86

0.955522425

0.48

0.036493987

0.33

0.000822847

hsa-miR-33a-3p

0.44

0.618581404

0.22

0.012191307

0.17

0.003599729

hsa-miR-3613-5p

0.88

0.962873516

0.36

0.002314

0.38

0.002622677

hsa-miR-424-3p

0.64

0.720598475

0.31

0.000695205

0.23

9.65E-06

hsa-miR-4466

0.53

0.50269118

0.13

1.23E-07

0.19

1.72E-05

hsa-miR-455-3p

1.29

0.904640745

0.46

0.026536474

0.45

0.016879484

hsa-miR-505-5p

0.73

0.866491946

0.36

0.001669409

0.35

0.000890148

hsa-miR-573

0.66

0.773087527

0.18

1.88E-07

0.09

4.29E-12

hsa-miR-92a-1-5p

0.59

0.720598475

0.22

0.000120735

0.20

2.52E-05

hsa-miR-93-3p

0.63

0.720598475

0.42

0.016836038

0.37

0.003599729

hsa-miR-940

1.11

0.962873516

0.32

0.002314

0.27

0.000255512

  1. MicroRNAs in each section of the table are arranged in numerical order for ease of reading. Fold-change in linear scale (FC) and adjusted p value (adj.p-val) are shown for each microRNA at each hypoxia time. MicroRNAs which regulation by hypoxia has not been reported before have been highlighted in bold.
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Molecular Cancer

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