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Figure 8 | Molecular Cancer

Figure 8

From: Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models

Figure 8

The orthotopic HN12shSET xenograft tumor model and lymph node metastasis. (A) Images of the tumors formed by the HN12shControl and HN12shSET cells in the tongue of Balb/c nude mice. After fifteen days, the animals were euthanized, and the tongue and lymph nodes were dissected. (B) Histopathological analysis of the orthotopic HN12shControl and shSET H&E-stained xenograft tumor sections. (C) Histopathological analysis of the cervical lymph nodes from the orthotopic HN12shSET xenograft tumor revealed the presence of metastatic cells 15 days after injection, whereas the lymph nodes in mice bearing HN12shControl xenograft tumors lacked metastatic cells.

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Molecular Cancer

ISSN: 1476-4598