Brain enriched miRNAs | Target | Function | Ref |
---|---|---|---|
miR-9* | SOX2 | Induces neuronal differentiation, affects both proliferation and differentiation | |
miRNA-128 | Reelin, DCX, SUZ12, neurofibromin 1, BMI1, RTK, EGFR,PDGFRαUPF1, MLN51, NTRK3, WEE1, Bax, E2F3a, SNAP25 | Synaptogenesis; reduces neuroblastoma cell motility and invasiveness; suppressor of PRC activity; renders glioma stemlike cells less radioresistant; suppressor of the colony formation ability and invasiveness of pituitary tumor cells; suppressor of growth and mediates differentiation; regulates Nonsense-mediated decay; regulates apoptosis, inhibits proliferation and self-renewal, | |
miR-7 | KLF4, α-synuclein, Sepp1b, EGFR, IRS-2 | Suppresses brain metastasis, control neurite outgrowth, protects against oxidative stress, potential tumor suppressor, decreases viability and invasiveness of primary glioblastoma | |
miR-125 a-b | NR2A, SMG1, SMAD4 | regulates synaptic plasticity; regulates Nonsense-mediated decay. | |
miR-23 | laminB1,X-linked inhibitor of apoptosis (XIAP) | regulates oligodendrocyte development and myelination, regulates cerebral ischemia and neural specification | |
miR-132 | PTBP2, AChE, FoxP2, Sirt1, MeCP2, ATA2, DPYSL3, STAT4; p250RhoGAP, Mecp2, Ep300, Jarid1a, Btg2, Paip2a, For more targets view[80] | Regulates progressive supranuclear palsy, regulator of the brain-to-body resolution of inflammation, contribute to neurodevelopmental and neuromorphological pathologies, neuronal cell development, regulate synaptic plasticity, neuronal maturation, regulates basal and activity-induced neurite outgrowth, regulates recognition memory and synaptic plasticity, regulates Circadian Clock. | |
miR-137 | CDK6, MindBomb-1, CSMD1, C10orf26, CACNA1C, TCF4, ZNF804A, neurofibromin 1, CSE1L, Cox-2, LSD1, MITF, EZH2, KLF4, SPTLC1, For more targets view[94] | Inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells, neuronal maturation, regulates differentiation of neural stem cells, suppress growth and invasion of oligodendroglioma and glioma cells, | |
miR-139 | Mcl-1, C-X-C chemokine receptor type 4 (CXCR4), FoxO1, CPG1, Bcl2 | Suppressor of the proliferation and enhances drug induced apoptosis, Reduced invasion and metastasis, Regulates Transcriptional activity. |