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Figure 6 | Molecular Cancer

Figure 6

From: CD8+T cell–specific induction of NKG2D receptor by doxorubicin plus interleukin-12 and its contribution to CD8+T cell accumulation in tumors

Figure 6

Association between level of NKG2D expression on splenocytes and antitumor efficacy in vivo. (A, B) Groups of tumor-bearing BALB/C mice (n = 5 per group) were subjected to one of the four standard treatments. Two independent experiments were performed. (A) Administration of anti-NKG2D antibody reduced Dox plus IL-12–mediated inhibition of tumor growth. Anti-NKG2D and IgG represent NKG2D-blocking antibody (clone C7) and control IgG antibody, respectively. The curves represent the tumor volumes as mean ± SEM. (B) Administration of anti-NKG2D antibody reduced Dox plus IL-12–mediated inhibition of metastatic tumor growth. The graph represents the numbers of lung metastases as the mean of number per lung ± SEM.

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