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Figure 1 | Molecular Cancer

Figure 1

From: Molecular subtyping of metastatic renal cell carcinoma: implications for targeted therapy

Figure 1

Metastatic clear cell renal cell carcinoma. A metastatic tumor nodule in the lung (A) was composed of solid, nested, and tubular arrangements of cells with clear cytoplasm (B). The tumor cells showed negative immunoreactivity for CK7 (C) but strong reactivity for AMACR (D). Dual-color fluorescence in situ hybridization demonstrated chromosome 3p deletion, as indicated by the presence of a single 3p25 signal (green) with two chromosome 3 centromere signals (red) per cell (E). Tumor nuclei showed two green signals for chromosome 7 and two red signals for chromosome 17 (F), disomic patterns.

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