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Figure 2 | Molecular Cancer

Figure 2

From: Molecular subtyping of metastatic renal cell carcinoma: implications for targeted therapy

Figure 2

Metastatic papillary renal cell carcinoma. A metastatic tumor nodule in the liver exhibited characteristic papillary architecture (A), composed of fibrovascular cores lined by cells with eosinophilic cytoplasm (B). The tumor cells labeled strongly with antibodies to CK7 (C) and AMACR (D). Dual-color fluorescence in situ hybridization revealed intact chromosome 3p, as indicated by two green signals (3p25) and two chromosome 3 centromeric red signals (CEP3) (E). Dual-color fluorescence in situ hybridization demonstrated trisomy of chromosomes 7 and 17, as evident by three green signals (CEP7) and three red signals (CEP17) in each tumor cell nucleus (F), supporting the classification of papillary renal cell carcinoma.

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