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Figure 4 | Molecular Cancer

Figure 4

From: NF-kappaB-dependent MicroRNA-425 upregulation promotes gastric cancer cell growth by targeting PTEN upon IL-1β induction

Figure 4

NF-kappaB binding sites in the miR-425 promoter. (A) Features of the miR-425 5’ flanking DNA. Human promoter regions of miR-425 contain three putative binding sites for NF-kappaB. (B) ChIP assays with anti-NF-kappaB antibodies showed binding of NF-kappaB to the promoter of miR-425 in AGS cells. The relative occupancies of NF-kappaB are indicated as vertical bars. The bar graphs show the averages of three independent ChIP experiments. (C) The promoter of miR-425 was activated by NF-kappaB. AGS cells were treated with NF-kappaB and transfected with the indicated LUC vectors.

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Molecular Cancer

ISSN: 1476-4598