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Figure 1 | Molecular Cancer

Figure 1

From: Cathepsin S-mediated autophagic flux in tumor-associated macrophages accelerate tumor development by promoting M2 polarization

Figure 1

Expression of Cat S in tumor tissues. (A) Quantitative real-time PCR analysis of the mRNA level of Cathepsin family members in human colon carcinoma and adjacent normal colon tissues (samples from 15 human adenocarcinoma tissues and the healthy adjacent tissue). GAPDH was a normalization control. **, P<0.01 vs adjacent normal colon tissues. (B) HE staining and immunohistochemical analysis of Cat S or macrophage marker CD68 expression in normal colon tissues and human colon carcinoma. Histopathological differentiation grade indicates well-, moderately- and poorly-differentiated. T indicates tumor invasion depth. N indicates lymph node metastasis. M indicates distant metastasis. (×200 magnification and Scale bars = 100 μm). Quantitative analysis of Cat S expression in tumor sections at different histologic grade (well, moderate and poor), different tumor stages (I–IV;) and with or without recurrence 3 years after operation (n = 5-10 samples per group, with 10 fields per samples). **, P<0.01.

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