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Figure 6 | Molecular Cancer

Figure 6

From: Synthesis, identification and in vivo studies of tumor-targeting agent peptide doxorubicin (PDOX) to treat peritoneal carcinomatosis of gastric cancer with similar efficacy but reduced toxicity

Figure 6

Light micrographs and electron transmission micrographs of rabbit myocardium. Top panel (HE stain, 400×), routine histopathological features of rabbit myocardium at longitudinal section (inserts on the upper right corner, sagittal section), where C1, H1 and P1 demonstrated clean and clear normal myocardial fibers in orderly arrays, but D1 showed coagulation necrosis of the myocardium with deep red stained cytoplasm and the karyopyknosis of the myocardium. Middle upper panel (10,000×), electron transmission micrographs of the myocardium focusing on the features of nuclei and peri-nuclear mitochondria, where C2, H2 showed abundant mitochondria packed around normal nucleus, P2 showed rich mitochondria scattered around normal nucleus, but D2 showed nearly absent mitochondria around the morphologically senile and degenerative nucleus (yellow star showing enlarged nucleus due to swelling and the eccentric aggregation of heterochromatin, and green arrows showing conspicuous inward contraction of the nuclear membrane ). In addition, partial myocardium-lytic necrosis (yellow arrow) and mitochondria-pyknosis away from the nucleus (red arrow) were also evident in DOX treated animals. Middle lower panel (20,000×), electron transmission micrographs of the myocardium specifically focusing on the detailed morphological changes of mitochondria, where C3 and H3 showed normal mitochondria morphology, P3 showed normal mitochondria morphology but with slightly dilated cristae in some mitochondria, but D3 showed conspicuous mitochondria-pyknosis with significantly smaller size and highly packed cristae (red arrows) and completely disintegrated mitochondria reducing to high electron-density bodies (blue arrows). Bottom panel (20,000×), electron transmission micrographs of the myocardium focusing on the detailed morphological changes of intercalated discs, where C4, H4 and P4 showed complete, clear and continuous lines of normal intercalated discs (white arrows), but D4 showed obscure, loosing and discontinuous intercalated discs (white arrows).

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