Synthesis, identification and in vivo studies of tumor-targeting agent peptide doxorubicin (PDOX) to treat peritoneal carcinomatosis of gastric cancer with similar efficacy but reduced toxicity

Table 2 Results of post mortem pathological study in 4 groups, expressed as % of rabbits

	Control (n = 10)	HIPEC (n = 10)	PDOX (n = 10)	DOX (n = 10)	p ₁	p ₂	p ₃	p ₄
Ulcerative GC	100.0	100.0	100.0	100.0	NS	NS	NS	NS
Incision metastases	100.0	30.0	30.0	20.0	0.001	NS	NS	NS
Pulmonary metastases	0.0	70.0	30.0	30.0	0.001	NS	NS	NS
Chest wall metastases	0.0	20.0	10.0	0.0	NS	NS	NS	NS
Pleural effusion	10.0	70.0	30.0	30.0	0.008	NS	NS	NS
Virchow lymph nodes metastases	30.0	70.0	60.0	40.0	NS	NS	NS	NS
Pericardium metastases	0.0	20.0	0.0	0.0	NS	NS	NS	NS
Cancerous diaphragm	100.0	70.0	20.0	20.0	NS	0.028	0.028	NS
Greater omentum cake	100.0	80.0	40.0	50.0	NS	NS	NS	NS
Liver metastases	80.0	40.0	30.0	30.0	NS	NS	NS	NS
Spleen metastases	0.0	0.0	20.0	0.0	NS	NS	NS	NS
Retroperitoneum metastases	100.0	60.0	60.0	50.0	0.029	NS	NS	NS
Left renal metastases	0.0	10.0	0.0	0.0	NS	NS	NS	NS
Right renal metastases	0.0	0.0	0.0	0.0	NS	NS	NS	NS
Kidney capsule invasion	100.0	50.0	0.0	20.0	0.012	0.012	NS	NS
Intestine wall seeding	100.0	80.0	20.0	10.0	NS	0.009	0.002	NS
Mesentery seeding	100.0	80.0	30.0	10.0	NS	0.028	0.002	NS
Abdominal wall cancer	100.0	60.0	30.0	0.0	0.029	NS	0.004	NS
Pelvic seeding	100.0	50.0	30.0	10.0	0.170	NS	NS	NS
Bladder rupture	0.0	0.0	20.0	10.0	NS	NS	NS	NS
Urine retention	50.0	50.0	30.0	10.0	NS	NS	NS	NS

By 2-sided chi-square (χ²) test. p₁, HIPEC vs. Control; p₂, PDOX vs. HIPEC; p₃, DOX vs. HIPEC; p₄, PDOX vs. DOX.
NS: no significance.
Compared with the Control, PC severity was significantly reduced in incision metastases, pulmonary metastases, pleural effusion, retroperitoneal metastases, kidney capsule invasion, abdominal wall cancer and pelvic seeding in the HIPEC. Compared with the HIPEC, PC severity was significantly reduced in the cancerous diaphragm, kidney capsule invasion, intestine wall seeding and mesentery seeding in the PDOX, and in the cancerous diaphragm, intestine wall seeding, mesentery seeding and abdominal wall cancer in the DOX. There were no statistical differences between the PDOX and DOX in systemic metastases.

ISSN: 1476-4598