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Table 3 Blood routine tests and biochemical test results in 4 groups of rabbits [range (median)]

From: Synthesis, identification and in vivo studies of tumor-targeting agent peptide doxorubicin (PDOX) to treat peritoneal carcinomatosis of gastric cancer with similar efficacy but reduced toxicity

Group

D2

D6

D14

D36*

n

Value

p

n

Value

p

n

Value

p

n

Value

p

Red blood cells (T/L)

Control

10

5.03-6.93 (6.26)

0.849

10

5.08-7.76 (6.07)

0.494

10

4.29-6.32 (5.54)

0.382

0

-

0.203

HIPEC

10

5.13-7.58 (6.48)

10

4.66-7.15 (5.65)

10

3.54-7.30 (5.68)

7

4.28-7.36 (5.28)

PDOX

10

4.17-7.16 (5.94)

10

4.97-6.49 (5.61)

10

4.38-5.82 (5.05)

10

4.46-6.03 (5.47)

DOX

10

5.03-6.84 (6.09)

10

5.03-6.70 (5.88)

10

3.65-6.36 (5.08)

9

4.12-6.40 (4.94)

White blood cells (G/L)

Control

10

5.3-9.6 (8.6)

0.785

10

4.5-14.1 (9.9)

0.446

10

6.0-10.3 (7.8)

0.601

0

-

0.013

HIPEC

10

4.4-12.3 (7.4)

10

4.5-12.7 (9.3)

10

3.2-12.1 (10.7)

7

6.9-13.7 (7.5)

PDOX

10

5.9-13.2 (8.2)

10

6.1-12.5 (8.8)

10

4.6-14.4 (9.0)

10

4.9-11.1 (7.7)

DOX

10

3.6-10.5 (7.8)

10

4.7-12.2 (7.3)

10

4.6-12.5 (10.2)

9

3.9-6.4 (5.3)

Platelets (G/L)

Control

10

387-579 (480)

0.494

10

317-836 (555)

0.362

10

451-917 (657)

0.601

0

-

0.009

HIPEC

10

229-634 (373)

10

363-758 (408)

10

390-709 (489)

7

262-598 (451)

PDOX

10

382-592 (456)

10

395-856 (493)

10

328-1002 (500)

10

201-532 (363)

DOX

10

330-647 (476)

10

363-878 (464)

10

390-939 (654)

9

115-319 (244)

Alanine transaminase (U/L)

Control

10

31-52 (38)

0.463

10

34-54 (41)

0.525

10

21-54 (37)

0.245

0

-

0.838

HIPEC

10

24-47 (40)

10

21-62 (35)

10

31-66 (42)

7

30-59 (48)

PDOX

10

28-52 (40)

10

24-59 (37)

10

32-55 (45)

9

25-79 (40)

DOX

10

29-59 (35)

10

30-59 (39)

10

34-61 (48)

8

26-76 (42)

Aspartate transaminase (U/L)

Control

10

19-54 (35)

0.895

10

30-52 (36)

0.525

10

37-58 (43)

0.309

0

-

0.473

HIPEC

10

23-59 (38)

10

11-55 (35)

10

27-78 (34)

7

25-50 (36)

PDOX

10

22-47 (37)

10

17-49 (39)

10

27-69 (36)

9

20-41 (30)

DOX

10

24-47 (37)

10

24-49 (30)

10

23-86 (36)

8

31-60 (39)

Blood urea nitrogen (mmol/L)

Control

10

4.40-5.80 (4.80)

0.206

10

4.51-10.44 (4.81)

0.525

10

3.29-9.82 (6.32)

0.185

0

-

0.473

HIPEC

10

3.70-8.14 (5.10)

10

3.57-11.04 (5.35)

10

4.32-9.29 (7.50)

7

5.25-8.67 (6.38)

PDOX

10

3.58-7.66 (5.82)

10

3.32-11.58 (6.68)

10

6.52-13.58 (7.63)

9

4.71-8.05 (5.35)

DOX

10

1.76-7.90 (5.01)

10

3.32-10.00 (5.59)

10

1.76-10.53 (7.80)

8

4.50-9.26 (6.27)

Creatinine (μmol/L)

Control

10

45.05-64.50 (60.50)

0.736

10

22.10-73.20 (55.00)

0.736

10

41.40-71.40 (50.25)

0.083

0

-

0.838

HIPEC

10

43.30-80.65 (57.35)

10

22.20-81.55 (46.97)

10

31.10-83.37 (52.96)

7

59.87-76.84 (66.51)

PDOX

10

42.80-75.80 (61.87)

10

22.13-86.25 (69.65)

10

45.30-75.80 (66.25)

9

44.38-79.56 (62.47)

DOX

10

22.30-69.30 (55.81)

10

27.28-75.90 (63.45)

10

42.38-73.76 (69.37)

8

47.72-78.64 (59.50)

Creatine kinase (U/L)

Control

10

74.3-205.6 (131.6)

0.864

10

81.3-247.8 (147.9)

0.878

10

71.4-182.1 (138.9)

0.968

0

-

0.473

HIPEC

10

78.8-259.2 (137.8)

10

66.8-248.9 (145.3)

10

63.4-225.2 (141.8)

7

98.3-265.1 (153.0)

PDOX

10

87.9-194.2 (139.4)

10

69.9-256.1 (144.4)

10

70.0-240.8 (130.6)

9

109.2-251.5 (195.2)

DOX

10

98.3-256.1 (152.4)

10

56.4-250.2 (135.8)

10

80.5-261.2 (133.8)

8

101.1-407.6 (228.1)

Creatine kinase mb isoenzyme (U/L)

Control

10

73.0-162.5 (129.8)

0.717

10

62.5-195.6 (127.2)

0.878

10

57.0-199.8 (119.8)

0.509

0

-

0.040

HIPEC

10

74.2-228.2 (137.3)

10

42.9-219.8 (129.7)

10

52.8-237.7 (146.5)

7

50.2-188.1 (126.1)

PDOX

10

59.2-228.1 (133.9)

10

42.5-197.7 (133.2)

10

74.9-241.5 (158.2)

9

58.9-209.8 (143.7)

DOX

10

94.3-207.7 (122.1)

10

53.9-202.3 (128.2)

10

94.3-238.6 (148.4)

8

106.2-656.5 (259.3)

  1. *Part of the data is not available because of animal death at the set time.
  2. By 2-sided nonparametric test.
  3. White blood cells on D 36, comparison between groups: p = 0.001, DOX vs. HIPEC; p = 1.000, PDOX vs. HIPEC; p = 0.005, PDOX vs. DOX; Platelets on D 36, comparison between groups: p = 0.041, DOX vs. HIPEC; p = 0.637, PDOX vs. HIPEC; p = 0.070, PDOX vs. DOX; Creatine kinase mb isoenzyme on D 36, comparison between groups: p = 0.012, DOX vs. HIPEC; p = 0.593, PDOX vs. HIPEC; p = 0.131, PDOX vs. DOX.
  4. Hematological toxicities with marked reduction in white blood cells (p < 0.05) and platelets (p < 0.05), as well as cardiac toxicities with significant increases in creatine kinase mb isoenzyme (p < 0.05) were observed on d 36 after systemic chemotherapy in the DOX.