Group | D2 | D6 | D14 | D36* | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
n | Value | p | n | Value | p | n | Value | p | n | Value | p | |
Red blood cells (T/L) | ||||||||||||
Control | 10 | 5.03-6.93 (6.26) | 0.849 | 10 | 5.08-7.76 (6.07) | 0.494 | 10 | 4.29-6.32 (5.54) | 0.382 | 0 | - | 0.203 |
HIPEC | 10 | 5.13-7.58 (6.48) | 10 | 4.66-7.15 (5.65) | 10 | 3.54-7.30 (5.68) | 7 | 4.28-7.36 (5.28) | ||||
PDOX | 10 | 4.17-7.16 (5.94) | 10 | 4.97-6.49 (5.61) | 10 | 4.38-5.82 (5.05) | 10 | 4.46-6.03 (5.47) | ||||
DOX | 10 | 5.03-6.84 (6.09) | 10 | 5.03-6.70 (5.88) | 10 | 3.65-6.36 (5.08) | 9 | 4.12-6.40 (4.94) | ||||
White blood cells (G/L) | ||||||||||||
Control | 10 | 5.3-9.6 (8.6) | 0.785 | 10 | 4.5-14.1 (9.9) | 0.446 | 10 | 6.0-10.3 (7.8) | 0.601 | 0 | - | 0.013 |
HIPEC | 10 | 4.4-12.3 (7.4) | 10 | 4.5-12.7 (9.3) | 10 | 3.2-12.1 (10.7) | 7 | 6.9-13.7 (7.5) | ||||
PDOX | 10 | 5.9-13.2 (8.2) | 10 | 6.1-12.5 (8.8) | 10 | 4.6-14.4 (9.0) | 10 | 4.9-11.1 (7.7) | ||||
DOX | 10 | 3.6-10.5 (7.8) | 10 | 4.7-12.2 (7.3) | 10 | 4.6-12.5 (10.2) | 9 | 3.9-6.4 (5.3) | ||||
Platelets (G/L) | ||||||||||||
Control | 10 | 387-579 (480) | 0.494 | 10 | 317-836 (555) | 0.362 | 10 | 451-917 (657) | 0.601 | 0 | - | 0.009 |
HIPEC | 10 | 229-634 (373) | 10 | 363-758 (408) | 10 | 390-709 (489) | 7 | 262-598 (451) | ||||
PDOX | 10 | 382-592 (456) | 10 | 395-856 (493) | 10 | 328-1002 (500) | 10 | 201-532 (363) | ||||
DOX | 10 | 330-647 (476) | 10 | 363-878 (464) | 10 | 390-939 (654) | 9 | 115-319 (244) | ||||
Alanine transaminase (U/L) | ||||||||||||
Control | 10 | 31-52 (38) | 0.463 | 10 | 34-54 (41) | 0.525 | 10 | 21-54 (37) | 0.245 | 0 | - | 0.838 |
HIPEC | 10 | 24-47 (40) | 10 | 21-62 (35) | 10 | 31-66 (42) | 7 | 30-59 (48) | ||||
PDOX | 10 | 28-52 (40) | 10 | 24-59 (37) | 10 | 32-55 (45) | 9 | 25-79 (40) | ||||
DOX | 10 | 29-59 (35) | 10 | 30-59 (39) | 10 | 34-61 (48) | 8 | 26-76 (42) | ||||
Aspartate transaminase (U/L) | ||||||||||||
Control | 10 | 19-54 (35) | 0.895 | 10 | 30-52 (36) | 0.525 | 10 | 37-58 (43) | 0.309 | 0 | - | 0.473 |
HIPEC | 10 | 23-59 (38) | 10 | 11-55 (35) | 10 | 27-78 (34) | 7 | 25-50 (36) | ||||
PDOX | 10 | 22-47 (37) | 10 | 17-49 (39) | 10 | 27-69 (36) | 9 | 20-41 (30) | ||||
DOX | 10 | 24-47 (37) | 10 | 24-49 (30) | 10 | 23-86 (36) | 8 | 31-60 (39) | ||||
Blood urea nitrogen (mmol/L) | ||||||||||||
Control | 10 | 4.40-5.80 (4.80) | 0.206 | 10 | 4.51-10.44 (4.81) | 0.525 | 10 | 3.29-9.82 (6.32) | 0.185 | 0 | - | 0.473 |
HIPEC | 10 | 3.70-8.14 (5.10) | 10 | 3.57-11.04 (5.35) | 10 | 4.32-9.29 (7.50) | 7 | 5.25-8.67 (6.38) | ||||
PDOX | 10 | 3.58-7.66 (5.82) | 10 | 3.32-11.58 (6.68) | 10 | 6.52-13.58 (7.63) | 9 | 4.71-8.05 (5.35) | ||||
DOX | 10 | 1.76-7.90 (5.01) | 10 | 3.32-10.00 (5.59) | 10 | 1.76-10.53 (7.80) | 8 | 4.50-9.26 (6.27) | ||||
Creatinine (μmol/L) | ||||||||||||
Control | 10 | 45.05-64.50 (60.50) | 0.736 | 10 | 22.10-73.20 (55.00) | 0.736 | 10 | 41.40-71.40 (50.25) | 0.083 | 0 | - | 0.838 |
HIPEC | 10 | 43.30-80.65 (57.35) | 10 | 22.20-81.55 (46.97) | 10 | 31.10-83.37 (52.96) | 7 | 59.87-76.84 (66.51) | ||||
PDOX | 10 | 42.80-75.80 (61.87) | 10 | 22.13-86.25 (69.65) | 10 | 45.30-75.80 (66.25) | 9 | 44.38-79.56 (62.47) | ||||
DOX | 10 | 22.30-69.30 (55.81) | 10 | 27.28-75.90 (63.45) | 10 | 42.38-73.76 (69.37) | 8 | 47.72-78.64 (59.50) | ||||
Creatine kinase (U/L) | ||||||||||||
Control | 10 | 74.3-205.6 (131.6) | 0.864 | 10 | 81.3-247.8 (147.9) | 0.878 | 10 | 71.4-182.1 (138.9) | 0.968 | 0 | - | 0.473 |
HIPEC | 10 | 78.8-259.2 (137.8) | 10 | 66.8-248.9 (145.3) | 10 | 63.4-225.2 (141.8) | 7 | 98.3-265.1 (153.0) | ||||
PDOX | 10 | 87.9-194.2 (139.4) | 10 | 69.9-256.1 (144.4) | 10 | 70.0-240.8 (130.6) | 9 | 109.2-251.5 (195.2) | ||||
DOX | 10 | 98.3-256.1 (152.4) | 10 | 56.4-250.2 (135.8) | 10 | 80.5-261.2 (133.8) | 8 | 101.1-407.6 (228.1) | ||||
Creatine kinase mb isoenzyme (U/L) | ||||||||||||
Control | 10 | 73.0-162.5 (129.8) | 0.717 | 10 | 62.5-195.6 (127.2) | 0.878 | 10 | 57.0-199.8 (119.8) | 0.509 | 0 | - | 0.040 |
HIPEC | 10 | 74.2-228.2 (137.3) | 10 | 42.9-219.8 (129.7) | 10 | 52.8-237.7 (146.5) | 7 | 50.2-188.1 (126.1) | ||||
PDOX | 10 | 59.2-228.1 (133.9) | 10 | 42.5-197.7 (133.2) | 10 | 74.9-241.5 (158.2) | 9 | 58.9-209.8 (143.7) | ||||
DOX | 10 | 94.3-207.7 (122.1) | 10 | 53.9-202.3 (128.2) | 10 | 94.3-238.6 (148.4) | 8 | 106.2-656.5 (259.3) |