Table 2 Patient-derived melanoma cultures with their B-RAF/N-RAS mutational status and sensitivity to RAF265 and MEK162
Name of the culture | Mutation | RAF265 IC50s [nM] | MEK162 IC50s [nM] | |
|---|---|---|---|---|
Wild type B-RAF /N-RAS | YUHOIN | WT | >1000 | >1000 |
YUROB | WT | 25 | 10 | |
YUROL | WT | >1000 | >1000 | |
YUSOC | WT | 72 | 36 | |
YUVON | WT | >1000 | >1000 | |
B-RAF mutants | YUCOT | V600E (GAG/GAG) | 35 | <1 |
YUGEN | V600E (GAG/GAG) | 5 | 108 | |
YUKOLI | V600E/WT (GAG/GTG) | 18 | 27 | |
YUKSI | V600K (AAG/AAG) | >1000 | 150 | |
YUMAC | V600K (AAG/AAG) | 208 | 8 | |
YURIF | V600K (AAG/AAG) | 412 | 45 | |
YUSAC | V600E (GAG/GAG) | >1000 | 148 | |
YUSIT | V600K/WT (AAG/GTG) | 188 | 25 | |
YUSUBA | V600E (GAG/GAG) | 660 | 50 | |
YUZEAL | V600R (AGG/AGG) | 124 | 33 | |
N-RAS mutants | YUCHER | Q61R (CGA/CGA) | 70 | 6 |
YUDOSO | Q61K/WT (AAA/CAA) | 62 | 9 | |
YUFIC | Q61R/WT (CGA/CAA) | 351 | 5 | |
YUGANK | Q61K (AAA/AAA) | >1000 | 5 | |
YUGASP | Q61L (CTA/CTA) | >1000 | 10 | |
YUKIM | Q61R (AGA/AGA) | 559 | 8 | |
YUTICA | Q61R/WT (CGA/CAA) | 371 | 13 |