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Table 2 Patient-derived melanoma cultures with their B-RAF/N-RAS mutational status and sensitivity to RAF265 and MEK162

From: MEK targeting in N-RAS mutated metastatic melanoma

  Name of the culture Mutation RAF265 IC50s [nM] MEK162 IC50s [nM]
Wild type
B-RAF /N-RAS
YUHOIN WT >1000 >1000
YUROB WT 25 10
YUROL WT >1000 >1000
YUSOC WT 72 36
YUVON WT >1000 >1000
B-RAF mutants YUCOT V600E (GAG/GAG) 35 <1
YUGEN V600E (GAG/GAG) 5 108
YUKOLI V600E/WT (GAG/GTG) 18 27
YUKSI V600K (AAG/AAG) >1000 150
YUMAC V600K (AAG/AAG) 208 8
YURIF V600K (AAG/AAG) 412 45
YUSAC V600E (GAG/GAG) >1000 148
YUSIT V600K/WT (AAG/GTG) 188 25
YUSUBA V600E (GAG/GAG) 660 50
YUZEAL V600R (AGG/AGG) 124 33
N-RAS mutants YUCHER Q61R (CGA/CGA) 70 6
YUDOSO Q61K/WT (AAA/CAA) 62 9
YUFIC Q61R/WT (CGA/CAA) 351 5
YUGANK Q61K (AAA/AAA) >1000 5
YUGASP Q61L (CTA/CTA) >1000 10
YUKIM Q61R (AGA/AGA) 559 8
YUTICA Q61R/WT (CGA/CAA) 371 13