Table 2 Afferent and efferent pairs in the crosstalk network
From: Aberrant gene expression in mucosa adjacent to tumor reveals a molecular crosstalk in colon cancer
AFFERENT PATHWAYS | |||
|---|---|---|---|
SECRETED BY ADJACENT MUCOSA | LOCATED IN TUMOR MEMBRANE | ||
Gene symbol | Function | Gene symbol | Function |
SLIT2 | Cell migration/axon guidance | ITGA1 | Integrin-mediated cellular signalling and axon guidance |
SLIT2 | ROBO2 | Cell migration/axon guidance | |
SLIT2 | ROBO1 | ||
SLIT3 | ROBO2 | ||
SLIT3 | ROBO1 | ||
SLIT2 | ROBO4 | Cell migration/angiogenesis | |
FGF7 | Growth factor activity | FGFR4 | Regulation of cell proliferation, differentiation and migration |
PTN | Growth factor with mitogenic activity | SDC3 | Organization of cell shape |
TIMP2 | Metalloendopeptidase inhibitor activity | MMP14 | Metalloendopeptidase activit (angiogenesis, cell proliferation…) |
MMP3 | Regulation of cell migration | MMP14 | |
SPOCK1 | Cell adhesion | MMP14 | |
ISG15 | Interferon-mediated signaling pathway | NEDD4 | Virus-host interaction |
VIP | Intestinal peptide that causes vasodilation | MME | Cellular response to cytokine stimulus |
MYOC | Anatomical structure morphogenesis | CD81 | Cell proliferation |
RELN | Neuron migration | LRP8 | Cytokine-mediated signalling pathway |
CLU | Platelet and complement activation | LRP8 | |
SERPING1 | Innate immunity | SELE | Inflammatory response |
CYR61 | Cell adhesion/chemotaxis | ITGA1 | integrin-mediated signaling pathway |
FIGF | Angiogenesis | ITGA9 | Integrin-mediated signaling pathway, cell adhesion |
HBEGF | Growth factor activity | CD82 | Metastasis suppressor gene |
CXCL12 | Immune response | CXCR4 | Inflammatory response |
CFH | Innate immunity | IGDCC4 | Inmunoglobulin |
CFD | Innate immunity | IGDCC4 | Â |
EFFERENT PATHWAYS | |||
SECRETED BY TUMOR | LOCATED IN ADJACENT MUCOSA MEMBRANE | ||
Gene symbol | Function | Gene symbol | Function |
IL8 | Inflammatory response | DARC | Inflammatory response |
MIF | Inflammatory response | CALD1 | Cellular component movement |
PLA1A | Lipid catabolic process | CALD1 | |
PF4 | Immune response and cytokine-mediated signaling pathway | LDLR | Lipid transport and metabolism |
WNT5A | In the presence of ROR2, inhibits the canonical Wnt pathway | ROR2 | Wnt receptor signaling pathway |
REG3A | Inflammatory response | SDC2 | Wound healing/carbohydrate metabolic process |
SPARC | Regulation of cell proliferation | SDC2 | |
KAL1 | Extracellular matrix structural constituent | SDC2 | |
PF4 | Immune response and cytokine-mediated signaling pathway | SDC2 | |
FN1 | Extracellular matrix structural constituent involved in multiple cellular functions | SDC2 | |
FN1 | ITGA5 | Angiogenesis/cell adhesion/wound healing | |
FN1 | IGDCC4 | Inmunoglobulin | |
FN1 | CD36 | Antigen processing and presentation, lipid storage, cell adhesion | |
FN1 | PECAM1 | Cell adhesion, signal transduction | |
TNC | Guidance of migrating neurons | CNTN1 | Notch signaling pathway, cell adhesion |
TNC | Â | ITGA5 | Angiogenesis/cell adhesion/wound healing |
TNC | Â | ITGA9 | Integrin-mediated signaling pathway, cell adhesion |
COL18A1 | Inhibits endothelial cell proliferation and angiogenesis | ITGA5 | Angiogenesis/cell adhesion/wound healing |
SFRP2 | Wnt receptor signaling pathway | ITGA5 | |
SPP1 | Cell adhesion, response to vitamin D | ITGA5 | |
SPP1 | ITGA9 | Integrin-mediated signaling pathway, cell adhesion | |
AGT | Renin-angiotensin system | AGTR1 | Inflammatory response, Rho protein signal transduction, Renin-angiotensin system |
AGT | CTSG | Immune response | |
APOC2 | Lipid metabolism | IGDCC4 | Inmunoglobulin |
PPBP | Chemotaxis and inmune response | IGDCC4 | |
PPBP | CTSG | Immune response | |
TAC1 | Peptide which excite neurons, and are potent vasodilators | TACR2 | Response to stress |
CXCL5 | Chemotaxis and inmune response | DARC | Inflammatory response |
CCL2 | Chemotaxis and inflammatory response | DARC | |
C4A | Inflammatory response | IGDCC4 | Inmunoglobulin |
IGHG1 | Innate inmune response | IGDCC4 | Â |
PCSK9 | Cellular response to starvation/cholesterol metabolic proces | LDLR | Lipid transport and metabolism |
MMP9 | Proteolysis | ITGA5 | Angiogenesis/cell adhesion/wound healing |
MMP9 | RECK | Blood vessel maturation | |
VEGFA | Growth factor active in angiogenesis | NRP2 | Angiogenesis |
PGF | Growth factor active in angiogenesis | NRP2 | |
ADAM12 | Epidermal growth factor receptor signaling pathway | ITGA9 | Integrin-mediated signaling pathway, cell adhesion |
COL4A1 | Angiogenesis | CD93 | Macrophage activation, cell-cell adhesion |
COL4A1 | CD36 | Antigen processing and presentation, lipid storage, cell adhesion | |
COL1A1 | Positive regulation of cell migration/positive regulation of epithelial to mesenchymal transition | DDR2 | Cell adhesion, ossification |
COL1A1 | ITGA5 | Angiogenesis/cell adhesion/wound healing | |
COL1A1 | CD93 | Macrophage activation, cell-cell adhesion | |
COL1A1 | CD36 | Antigen processing and presentation, lipid storage, cell adhesion | |
COL1A2 | Transforming growth factor beta receptor signaling pathway/platelet activation/leukocyte migration | CD93 | Macrophage activation, cell-cell adhesion |
COL1A2 | CD36 | Antigen processing and presentation, lipid storage, cell adhesion | |
COL3A1 | Integrin-mediated signaling pathway/blood vessel develpment | DDR2 | Cell adhesion, ossification |
COL6A1 | Axon guidance/cell adhesion | CD36 | Antigen processing and presentation, lipid storage, cell adhesion |
COL6A3 | Axon guidance/cell adhesion | ITGA5 | Angiogenesis/cell adhesion/wound healing |
COL4A2 | Cellular response to transforming growth factor beta stimulus/axon guidance/angiogenesis | CD93 | Macrophage activation, cell-cell adhesion |
COL4A2 | CD36 | Antigen processing and presentation, lipid storage, cell adhesion | |
LAMA4 | Cell adhesion | ITGA5 | Angiogenesis/cell adhesion/wound healing |
CFB | Complement activation | IGDCC4 | Inmunoglobulin |
SEMA3F | Cell migration | NRP2 | Angiogenesis |
EFNA3 | Cell-cell signalling | EPHA3 | Cell adhesion and migration |
C3 | Complement activation/Fatty acid metabolism | CTSG | Immune response |
INHBA | Cell surface receptor signaling pathway | TGFBR3 | Negative regulation of transforming growth factor beta receptor signaling pathway |
LIF | Growth factor activity | LIFR | Cell proliferation |
FN1 | Cell adhesion, cell motility, wound healing | FGFR1 | Cell proliferation, differentiation and migration |
IGHG1 | Complement activation | FGFR1 | |
ELN | Extracellular matrix organization, cell proliferation | FGFR1 | |
C3 | Complement activation | FGFR1 | Â |