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Table 2 Afferent and efferent pairs in the crosstalk network

From: Aberrant gene expression in mucosa adjacent to tumor reveals a molecular crosstalk in colon cancer

AFFERENT PATHWAYS
SECRETED BY ADJACENT MUCOSA LOCATED IN TUMOR MEMBRANE
Gene symbol Function Gene symbol Function
SLIT2 Cell migration/axon guidance ITGA1 Integrin-mediated cellular signalling and axon guidance
SLIT2 ROBO2 Cell migration/axon guidance
SLIT2 ROBO1
SLIT3 ROBO2
SLIT3 ROBO1
SLIT2 ROBO4 Cell migration/angiogenesis
FGF7 Growth factor activity FGFR4 Regulation of cell proliferation, differentiation and migration
PTN Growth factor with mitogenic activity SDC3 Organization of cell shape
TIMP2 Metalloendopeptidase inhibitor activity MMP14 Metalloendopeptidase activit (angiogenesis, cell proliferation…)
MMP3 Regulation of cell migration MMP14
SPOCK1 Cell adhesion MMP14
ISG15 Interferon-mediated signaling pathway NEDD4 Virus-host interaction
VIP Intestinal peptide that causes vasodilation MME Cellular response to cytokine stimulus
MYOC Anatomical structure morphogenesis CD81 Cell proliferation
RELN Neuron migration LRP8 Cytokine-mediated signalling pathway
CLU Platelet and complement activation LRP8
SERPING1 Innate immunity SELE Inflammatory response
CYR61 Cell adhesion/chemotaxis ITGA1 integrin-mediated signaling pathway
FIGF Angiogenesis ITGA9 Integrin-mediated signaling pathway, cell adhesion
HBEGF Growth factor activity CD82 Metastasis suppressor gene
CXCL12 Immune response CXCR4 Inflammatory response
CFH Innate immunity IGDCC4 Inmunoglobulin
CFD Innate immunity IGDCC4  
EFFERENT PATHWAYS
SECRETED BY TUMOR LOCATED IN ADJACENT MUCOSA MEMBRANE
Gene symbol Function Gene symbol Function
IL8 Inflammatory response DARC Inflammatory response
MIF Inflammatory response CALD1 Cellular component movement
PLA1A Lipid catabolic process CALD1
PF4 Immune response and cytokine-mediated signaling pathway LDLR Lipid transport and metabolism
WNT5A In the presence of ROR2, inhibits the canonical Wnt pathway ROR2 Wnt receptor signaling pathway
REG3A Inflammatory response SDC2 Wound healing/carbohydrate metabolic process
SPARC Regulation of cell proliferation SDC2
KAL1 Extracellular matrix structural constituent SDC2
PF4 Immune response and cytokine-mediated signaling pathway SDC2
FN1 Extracellular matrix structural constituent involved in multiple cellular functions SDC2
FN1 ITGA5 Angiogenesis/cell adhesion/wound healing
FN1 IGDCC4 Inmunoglobulin
FN1 CD36 Antigen processing and presentation, lipid storage, cell adhesion
FN1 PECAM1 Cell adhesion, signal transduction
TNC Guidance of migrating neurons CNTN1 Notch signaling pathway, cell adhesion
TNC   ITGA5 Angiogenesis/cell adhesion/wound healing
TNC   ITGA9 Integrin-mediated signaling pathway, cell adhesion
COL18A1 Inhibits endothelial cell proliferation and angiogenesis ITGA5 Angiogenesis/cell adhesion/wound healing
SFRP2 Wnt receptor signaling pathway ITGA5
SPP1 Cell adhesion, response to vitamin D ITGA5
SPP1 ITGA9 Integrin-mediated signaling pathway, cell adhesion
AGT Renin-angiotensin system AGTR1 Inflammatory response, Rho protein signal transduction, Renin-angiotensin system
AGT CTSG Immune response
APOC2 Lipid metabolism IGDCC4 Inmunoglobulin
PPBP Chemotaxis and inmune response IGDCC4
PPBP CTSG Immune response
TAC1 Peptide which excite neurons, and are potent vasodilators TACR2 Response to stress
CXCL5 Chemotaxis and inmune response DARC Inflammatory response
CCL2 Chemotaxis and inflammatory response DARC
C4A Inflammatory response IGDCC4 Inmunoglobulin
IGHG1 Innate inmune response IGDCC4  
PCSK9 Cellular response to starvation/cholesterol metabolic proces LDLR Lipid transport and metabolism
MMP9 Proteolysis ITGA5 Angiogenesis/cell adhesion/wound healing
MMP9 RECK Blood vessel maturation
VEGFA Growth factor active in angiogenesis NRP2 Angiogenesis
PGF Growth factor active in angiogenesis NRP2
ADAM12 Epidermal growth factor receptor signaling pathway ITGA9 Integrin-mediated signaling pathway, cell adhesion
COL4A1 Angiogenesis CD93 Macrophage activation, cell-cell adhesion
COL4A1 CD36 Antigen processing and presentation, lipid storage, cell adhesion
COL1A1 Positive regulation of cell migration/positive regulation of epithelial to mesenchymal transition DDR2 Cell adhesion, ossification
COL1A1 ITGA5 Angiogenesis/cell adhesion/wound healing
COL1A1 CD93 Macrophage activation, cell-cell adhesion
COL1A1 CD36 Antigen processing and presentation, lipid storage, cell adhesion
COL1A2 Transforming growth factor beta receptor signaling pathway/platelet activation/leukocyte migration CD93 Macrophage activation, cell-cell adhesion
COL1A2 CD36 Antigen processing and presentation, lipid storage, cell adhesion
COL3A1 Integrin-mediated signaling pathway/blood vessel develpment DDR2 Cell adhesion, ossification
COL6A1 Axon guidance/cell adhesion CD36 Antigen processing and presentation, lipid storage, cell adhesion
COL6A3 Axon guidance/cell adhesion ITGA5 Angiogenesis/cell adhesion/wound healing
COL4A2 Cellular response to transforming growth factor beta stimulus/axon guidance/angiogenesis CD93 Macrophage activation, cell-cell adhesion
COL4A2 CD36 Antigen processing and presentation, lipid storage, cell adhesion
LAMA4 Cell adhesion ITGA5 Angiogenesis/cell adhesion/wound healing
CFB Complement activation IGDCC4 Inmunoglobulin
SEMA3F Cell migration NRP2 Angiogenesis
EFNA3 Cell-cell signalling EPHA3 Cell adhesion and migration
C3 Complement activation/Fatty acid metabolism CTSG Immune response
INHBA Cell surface receptor signaling pathway TGFBR3 Negative regulation of transforming growth factor beta receptor signaling pathway
LIF Growth factor activity LIFR Cell proliferation
FN1 Cell adhesion, cell motility, wound healing FGFR1 Cell proliferation, differentiation and migration
IGHG1 Complement activation FGFR1
ELN Extracellular matrix organization, cell proliferation FGFR1
C3 Complement activation FGFR1