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Figure 1 | Molecular Cancer

Figure 1

From: Chemoprevention of dietary digitoflavone on colitis-associated colon tumorigenesis through inducing Nrf2 signaling pathway and inhibition of inflammation

Figure 1

Effects of digitoflavone on ARE–luciferase activity. (A) Chemical structure of digitoflavone (3, 0, 4, 5, 7-tetrahydroxyflavone). Its molecular weight is 286.23. (B-C) Effects of digitoflavone on ARE–luciferase activity in Caco-2 and HT-29 cells. Caco-2 cells were treated with various concentrations of digitoflavone for 8 hours and 24 hours respectively, luciferase activity was assayed as described in Materials and Methods. (D-E) HEK-293 cells, HepG2 cells were treated with various concentrations of digitoflavone for 8 hours and luciferase activity were assayed as described in Materials and Methods. (F) Cell viability of digitoflavone in Caco-2, HT-29, HepG2 and HEK-293 cells. Cells were treated with various concentrations (1–20 μM) of digitoflavone for 24 hours, cell viability were determined using MTT assay. Values were expressed as mean ± SD of triplicate experiments. Significantly different (versus control group): *p<0.05 and **p<0.01.

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Molecular Cancer

ISSN: 1476-4598