Skip to main content
Figure 4 | Molecular Cancer

Figure 4

From: Reduced expression of AMPK-β1 during tumor progression enhances the oncogenic capacity of advanced ovarian cancer

Figure 4

AMPK-β1 regulates cell migration and invasion of ovarian cancer cells. Enhanced expression of AMPK-β1 in SKOV3 (C1 and C3) cells resulted in a reduced cell migratory rate (3 to 3.5-fold) using (A) the transwell cell migration assay (P < 0.005) and a 3.5-fold decrease in the cell invasive rate using (B) the transwell cell invasion assay (P < 0.001). Conversely, depletion of endogenous AMPK-β1 in OVCA433 (C1 and C12) by shRNA knockdown enhanced the cell migration rate by 8- to 12-fold using (C) the transwell cell migration assay (P < 0.001) and resulted in a 7- to 12-fold increase in the cell invasive rate using (D) the transwell cell invasion assay (P < 0.0001). V1 and V2 are the empty vector controls for OVCA433 and SKOV3, respectively.

Back to article page

Molecular Cancer

ISSN: 1476-4598