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Table 2 Drugs that alter PC3 gene expression most similarly to ETV4 depletion

From: Prostate cancer ETS rearrangements switch a cell migration gene expression program from RAS/ERK to PI3K/AKT regulation

Rank

Drug

Target

P value

1

Sirolimus (Rapamycin)

mTOR

<0.00001

2

LY-294002

PI3K

<0.00001

3

Trichostatin A

HDAC

0.00002

4

Alexidine

Tyrosine Phosphatase

0.00004

5

Wortmannin

PI3K

0.00006

  1. Gene expression changes from small molecule treatments of PC3 cells in the Connectivity Map database [29] were compared to gene expression changes previously reported for ETV4 depletion in PC3 cells [25]. Small molecules that elucidated changes most similar to ETV4 depletion are rank ordered by P value.
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Molecular Cancer

ISSN: 1476-4598