Skip to main content
Figure 1 | Molecular Cancer

Figure 1

From: RETRACTED ARTICLE: Exemestane blocks mesothelioma growth through downregulation of cAMP, pCREB and CD44 implicating new treatment option in patients affected by this disease

Figure 1

Exemestane acts on MPM cell growth, cell-cycle progression and migration. A, NCI was not very sensitive to exemestane (EXE), only 70 μM of drug for 48 h had a significant response versus untreated (CNTR) cells; B, exemestane was not effective in Met-5A. Significant decrease in MSTO cell growth was observed upon different exemestane dosage treatment as per XTT (A), manual cell counting (C) and clonogenicity assays (35 μM exemestane) (D). E, exemestane (35 μM) induced cell cycle arrest in S-phase; F, Western blotting showed increase in p21 and decrease in Bcl-2 and Bcl-xL expression. G, reduced MPM cell lines sensitive migration in response to 35 μM exemestane treatment was identified by wound healing assay. Cell migration was not inhibited in NCI. Graphs represent the average of at least 3 repeated experiments; *, statistically significant effects (P < 0.05).

Back to article page

Molecular Cancer

ISSN: 1476-4598