Skip to main content
Figure 1 | Molecular Cancer

Figure 1

From: YC-1 enhances the anti-tumor activity of sorafenib through inhibition of signal transducer and activator of transcription 3 (STAT3) in hepatocellular carcinoma

Figure 1

Sorafenib-YC-1 combination synergistically inhibited proliferation of HCC cells. A, HepG2, BEL-7402 and HCCLM3 cells were incubated with increasing doses of sorafenib (0–20 μmol/L) or YC-1 (0–50 μmol/L) for up to 72 h. Data were presented as percentages of cell proliferation as determined by CCK-8 assays. B, HepG2, BEL-7402 and HCCLM3 cells were incubated with sorafenib (0–5 μmol/L) and/or YC-1 (0–20 μmol/L) for up to 72 h. Data were presented as percentages of cell proliferation as determined by CCK-8 assays. C, HepG2, BEL-7402 and HCCLM3 cells were treated sorafenib (2.5 μmol/L or 5 μmol/L) or YC-1 (10 μmol/L or 20 μmol/L) or in combination. The colonies were assessed. D, Synergisms of proliferation inhibition of different cell lines were analyzed by isobologram analysis. Error bars represent the SEM of data obtained in at least three independent experiments.

Back to article page

Molecular Cancer

ISSN: 1476-4598