Figure 4
From: Autophagic flux determines cell death and survival in response to Apo2L/TRAIL (dulanermin)
Autophagy inhibition prevents cell death in PC3 but enhances cell death in C4-2 cells. (A) Clonogenic survival assay in PC3 and C4-2 cells following TR (40 ng/ml) ± 3-methyladenine (3-MA) (*p < 0.001). (B) Clonogenic survival assay following TR ± CQ (*P < 0.001). Clonogenic survival in (C) C4-2 and (D) PC3 cells stably expressing non-target shRNA, shATG7, or shLAMP2, with the indicated doses of TR (*p < 0.001).