Figure 4From: miR-630 targets IGF1R to regulate response to HER-targeting drugs and overall cancer cell progression in HER2 over-expressing breast cancerOver-expression of miR-630 in lapatinib resistant cells decreases cell motility, migration, invasion and anoikis. Following transfection with miR-630 mimic or a negative control (NC) mimic in HCC1954-LR (i) and SKBR3-LR (ii) (A) motility, assessed by wound-healing assay; (B) migration, through transwells; (C) invasion, through ECM-coated transwells; (D) anoikis, on Poly(hydroxyethyl methacrylic) acid coated plates; were found to be significantly altered as a consequence of miR-630 induced expression. Results represent n = 3 ± SEM, where * p <0.05, ** p <0.01, ***p<0.001.Back to article page