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Figure 1 | Molecular Cancer

Figure 1

From: Integrated genomic analysis identifies the mitotic checkpoint kinase WEE1 as a novel therapeutic target in medulloblastoma

Figure 1

Analysis of cell cycle-related kinases in medulloblastoma. (A) Schematic of the integrated genomic analysis undertaken to identify novel targets in medulloblastoma. This approach identified 50 potential cell cycle-related kinases in medulloblastoma. (B) Heat map showing the gene expression of the 50 identified dysregulated cell cycle-related kinases in 16 medulloblastoma patient samples compared to three normal cerebellum samples. (C) Dot plot showing the average Z score for the 710 human kinase genes targeted in the siRNA screen. Each dot represents the average Z score of the 3 separate siRNAs targeting that single kinase. (D) The table lists the top 12 kinase genes with the lowest Z score from the siRNA screen performed in Daoy medulloblastoma cells.

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Molecular Cancer

ISSN: 1476-4598