Figure 6
Effect of porphyrins on melanoma tumour-bearing mice. (A) The mice with a melanoma tumour of about 8 mm were randomized in 5 groups, each of 8 mice. Group 1 was untreated. Groups 2 and 3 were treated with 30 mg/Kg of P2 and P4; groups 4 and 5 were treated with P2 and P4 (30 mg/Kg) then irradiated with a laser at 660 ± 5 nm (193 J/cm2), 9 h after delivery; (B) The mice were treated as follows. Group 1, untreated; group 2, treated with 3 mg/Kg of C14; group 3, treated with 3 mg/Kg C14 and irradiated. Three treatments have been carried out: at days 1, 7 and 14. A statistical analysis by ANOVA is reported. Each point of the curves is the average of 8 values (8 mice); (C) Kaplan-Meir showing the median survival time of the treated mice compared to untreated (control) or mice treated with the porphyrin but not irradiated.