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Figure 1 | Molecular Cancer

Figure 1

From: Divergent effects of muscarinic receptor subtype gene ablation on murine colon tumorigenesis reveals association of M3R and zinc finger protein 277 expression in colon neoplasia

Figure 1

Study protocol, animal weights, colon length and histological appearance of colon sections from mice with different Chrm genotypes. A: Schematic of study design; WT, Chrm3-/-, Chrm1-/- and dual KO male mice were treated with intraperitoneal injection of AOM (10 mg/kg) or an equal volume of vehicle (phosphate buffered saline) weekly for 6 weeks and followed for a total of 20 weeks. At 20 weeks, animals were euthanized and colon tumor number and size, and mucosal markers of proliferation and apoptosis were measured. B: Weights of AOM-treated mice during the 20-week study (mean ± S.E.). C: Colon length of AOM-treated mice was measured following euthanasia at 20 weeks (mean ± S.E.). D No morphological differences were seen in hematoxylin and eosin (H&E)-stained microscopic sections of normal colon tissue from WT, Chrm3-/-, Chrm1-/- and dual KO mice. Size bars = 50 micrometers.

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Molecular Cancer

ISSN: 1476-4598