Figure 2From: Divergent effects of muscarinic receptor subtype gene ablation on murine colon tumorigenesis reveals association of M3R and zinc finger protein 277 expression in colon neoplasiaMeasurement of colon tumor number and size 20 weeks after starting AOM treatment. A: Representative photographs of resected distal colon from AOM-treated mice with different Chrm genotypes. B: Tumor number was reduced in AOM-treated Chrm3-/- compared to WT mice (P < 0.05). There was no significant difference in tumor number in Chrm1-/- and dual KO compared to WT mice (mean ± S.E.). C: Reduced tumor volume in Chrm3-/- compared to WT mice (P < 0.005). Tumor volume in Chrm1-/- and dual KO compared to WT mice was not significantly different (mean ± S.E.). D: Histogram of tumor volume in AOM-treated WT, Chrm3-/-, Chrm1-/- and dual KO mice. E: Numbers of adenomas and adenocarcinomas per section in AOM-treated WT, Chrm3-/-, Chrm1-/- and dual KO mice.Back to article page