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Figure 2 | Molecular Cancer

Figure 2

From: Divergent effects of muscarinic receptor subtype gene ablation on murine colon tumorigenesis reveals association of M3R and zinc finger protein 277 expression in colon neoplasia

Figure 2

Measurement of colon tumor number and size 20 weeks after starting AOM treatment. A: Representative photographs of resected distal colon from AOM-treated mice with different Chrm genotypes. B: Tumor number was reduced in AOM-treated Chrm3-/- compared to WT mice (P < 0.05). There was no significant difference in tumor number in Chrm1-/- and dual KO compared to WT mice (mean ± S.E.). C: Reduced tumor volume in Chrm3-/- compared to WT mice (P < 0.005). Tumor volume in Chrm1-/- and dual KO compared to WT mice was not significantly different (mean ± S.E.). D: Histogram of tumor volume in AOM-treated WT, Chrm3-/-, Chrm1-/- and dual KO mice. E: Numbers of adenomas and adenocarcinomas per section in AOM-treated WT, Chrm3-/-, Chrm1-/- and dual KO mice.

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