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Figure 2 | Molecular Cancer

Figure 2

From: Cisplatin-induced epigenetic activation of miR-34a sensitizes bladder cancer cells to chemotherapy

Figure 2

Expression of miR-34a increased in MIBC cell lines via promoter demethylation following cisplatin treatment. Cisplatin induced miR-34a expression in A) doze- and B) time-dependent manner, relative to control group ( cisplatin 0 μg/ml group or 0 h group, mean + SEM; n = 3; *p < 0.05). Methylation analysis of miR-34a promoter region: C) profiling of the unit-specific methylation of CpG sites in the miR-34a promoter region was presented as an epigram; D) Average methylation level of miR-34a promoter region in MIBC cell lines (mean + SEM; n = 3; *p < 0.05).

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