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Figure 6 | Molecular Cancer

Figure 6

From: Cisplatin-induced epigenetic activation of miR-34a sensitizes bladder cancer cells to chemotherapy

Figure 6

The tumor-suppressive and chemosensitivity functions of miR-34a were mediated by reduction the production of CD44. Downregulation of CD44 by siRNA led to similar effect of miR-34a overexpression on A) cell proliferation (mean ± SEM; n = 3; *p < 0.05) and B-C) tumorigenity (mean + SEM; n = 3; *p < 0.05). Increased CD44 expression could efficiently reverse the effect of miR-34a on MIBC D) cell proliferation (mean ± SEM; n = 3; *p < 0.05), E-F) colongenic potential and G) chemosensitivity (mean + SEM; n = 3; *p < 0.05).

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