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Figure 5 | Molecular Cancer

Figure 5

From: Targeting gallbladder cancer: oncolytic virotherapy with myxoma virus is enhanced by rapamycin in vitro and further improved by hyaluronan in vivo

Figure 5

HA–CD44 interaction increases Akt activation and promotes myxoma virus oncolysis in GBC cells in vitro . A. Western blotting results of p-Akt and total Akt expression in GBC cell lines (GBC-SD, SGC-996) or the glioma cell line (U251) pretreated with MYXV (Myx), Myx + Rap, Myx + HA, or Myx + HA + anti-CD44 mAb. B. Relative gray scale of p-Akt values from each group (*, P < 0.05 compared with the control group). C. Oncolytic effects of MYXV on gallbladder cancer cell lines in vitro. GBC-SD, SGC-996, and U251 were infected with control Dead Virus (DV), Myx, Myx + Rap, HA, Myx + HA, Myx + HA + anti-CD44 mAb, or Myx + HA + isotype mAb (*, P < 0.05 compared with the control group).

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Molecular Cancer

ISSN: 1476-4598