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Figure 5 | Molecular Cancer

Figure 5

From: Targeted delivery of CD40L promotes restricted activation of antigen-presenting cells and induction of cancer cell death

Figure 5

CD20-restricted paracrine maturation of immature DC by anti-CD20:CD40L. A iDC were co-cultured overnight with BJAB in the presence or absence of either 30, 100 or 300 ng/mL anti-CD20:CD40L ± parental antibody Rituximab or irrelevant isotype control. iDC maturation was assessed by determining the concentration of IL-12/23 in the culture supernatant. B Indicated mono- and co-cultures of iDC and Jurkat T leukemia cells were treated overnight with 30 or 300 ng/mL anti-CD20:CD40L ± Rituximab. iDC maturation was assessed by determining the concentration of IL-12/23 in the culture supernatant. C iDC were co-cultured overnight with the indicated tumor cell lines in the presence or absence of 30 or 300 ng/mL anti-CD20:CD40L ± Rituximab. iDC maturation was assessed by determining the concentration of IL-12/23 in the culture supernatant.

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