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Table 1 Relationship between miR-181a expression and pathological features in CRC patients

From: MicroRNA-181a promotes tumor growth and liver metastasis in colorectal cancer by targeting the tumor suppressor WIF-1

 

miR-181a expression (RQ: 2 − ΔCt)

 

Variable

Case no.

Median

Range

p

Gender

   

0.646

 Male

77

0.002267

0.00028409-0.086144702

 

 Female

60

0.002338

0.000051016-0.016974115

 

Age

   

0.118

 ≤60(median)

64

0.0026165970

0.000051016-0.040007408

 

 >60

73

0.0018319950

0.000215355-0.086144702

 

Venous invasion

   

0.18

 Positive

50

0.002491

0.000473623-0.086144702

 

 Negative

87

0.002013

0.000051016-0.017423945

 

T stage

   

< 0.0001

 T1

1

0.0003546

  

 T2

12

0.000522

0.000215-0.002013

 

 T3

102

0.002697

0.000051-0.0635

 

 T4

22

0.003080

0.000286-0.08614

 

N stage

   

0.0362

 N0

55

0.001813

0.000215-0.0635

 

 N1

40

0.002767

0.000286-0.08615

 

 N2

42

0.002537

0.000051-0.01697

 

M stage

   

0.0023

 M0

74

0.002008

0.000051-0.01697

 

 M1

63

0.003277

0.000606-0.08615

 

TNM stage

   

< 0.0001

 I

12

0.0004145

0.000215-0.002013

 

 П

33

0.002306

0.000421-0.01586

 

 III

29

0.002267

0.000051-0.01697

 

 IV

63

0.002653

0.000353-0.08615

 

Differentiation

   

0.4114

 Poor

32

0.002538

0.000051-0.01577

 

 Moderate

76

0.002425

0.000266-0.08615

 

 Well

29

0.001738

0.000233-0.04001

 

Histological type

    

 Adenocarcinoma

130

0.002339

0.000215-0.08615

0.5348

 Mucinous adenocarcinoma

7

0.001962

0.000051-0.006384

 
  1. Quantified by stem–loop-based qRT–PCR. miR-181a was normalized to U6. Mann–Whitney test for the comparison between two groups or Kruskal–Walis test for more groups.