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Figure 2 | Molecular Cancer

Figure 2

From: A 3′UTR polymorphism modulates mRNA stability of the oncogene and drug target Polo-like Kinase 1

Figure 2

In silico transcription factor binding sites and electrophoretic mobility shift assay. Schematic representation of the PLK1 silencer and core promoter regions (panel A). Alleles and the surrounding sequence of the silencer SNP rs57973275 (c.-1706G > A) and the core promoter SNP rs16972787 (c.-233G > A) are shown. Transcription factors and their putative binding sites are shown above and below the corresponding PLK1 alleles, respectively. Representative electrophoretic mobility shift assays for both SNPs that failed to show genotype-dependent binding of nuclear extracts of different cell lines (panel B).

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