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Table 1 Gene expression changes in SRSF2-over-expressing H358 lung adenocarcinoma cells

From: A dedicated microarray for in-depth analysis of pre-mRNA splicing events: application to the study of genes involved in the response to targeted anticancer therapies

Gene regulation

Gene symbol

Control condition intensity

SRSF2 condition intensity

Regulation

Fold-change

P-value

Up-regulated

VEGFA

9.25

9.99

up

1.67

3.38E-08

Down-regulated

HER1/EGFR

5.01

4.11

down

1.87

3.65E-06

Slightly down-regulated

HER3

2.33

1.78

down

1.47

3.98E-03

 

HIF1A

6.48

6.06

down

1.33

2.04E-04

 

PIR

7.01

6.62

down

1.32

1.82E-03

 

AKT1

8.04

7.68

down

1.28

8.15E-05

 

VEGFB

7.84

7.48

down

1.28

2.56E-04

Not regulated

PIK3R2

3.94

4.19

up

1.19

1.62E-01

 

AKT3

2,00

1.91

down

1.06

6.18E-01

 

HER2

4.89

4.81

down

1.05

4.01E-01

 

AKT2

5.81

5.74

down

1.05

5.57E-01

 

VEGFC

5.90

5.89

down

1.01

9.03E-01

Not expressed

PIK3R1

1.35

1.89

up

1.45

3.71E-02

 

VEGFD

0.88

0.98

up

1.07

8.23E-02

 

HER4

0.65

0.69

up

1.03

4.87E-01

 

PIK3CA

1.79

1.78

down

1.01

8.58E-01

  1. The expression and the regulation of the 16 genes were analyzed on the 15 k custom microarray in SRSF2-over-expressing H358 lung cancer cells in comparison to control cells. Some genes were not expressed; others were not differentially expressed. Five genes were slightly down-regulated (≤ 1.5 FC, P-value ≤ 0.05), and one gene (HER1/EGFR) was more strongly down-regulated (≥ 1.5 FC, P-value ≤ 0.05). Only one gene (VEGFA) was up-regulated in the SRSF2 over-expression condition (≥ 1.5 FC, P-value ≤ 0.05).