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Figure 5 | Molecular Cancer

Figure 5

From: Epidithiodiketopiperazines (ETPs) exhibit in vitro antiangiogenic and in vivo antitumor activity by disrupting the HIF-1α/p300 complex in a preclinical model of prostate cancer

Figure 5

ETPs attenuate tumor growth in vivo . A, Mice with approximately 100 mm3 PC3 xenografts were treated by daily intraperitoneal injection for 15 days with gliotoxin (0.50 mg/kg), chaetocin (0.25 mg/kg), chetomin (0.50 mg/kg), or vehicle control (top panel). Mice with approximately 100 mm3 DU-145 xenografts were treated by daily intraperitoneal injection for 15 days with gliotoxin (0.50 mg/kg) or vehicle control (bottom panel). Results are the mean of 6–7 independent tumors ± S.E.M. B, Graphical representation of the percent of animals with varying degrees of necrosis (top panel). Statistical significance was determined using the Mann–Whitney U test. *, p < 0.05, **, p < 0.005. Low-power views (2x and 10x) of H & E-stained tumor sections from PC3 xenografts (bottom panel). The arrows indicate areas of necrosis in vehicle- and gliotoxin-treated tumors, which had the highest incidence of necrosis.

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