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Figure 4 | Molecular Cancer

Figure 4

From: The negative interplay between Aurora A/B and BRCA1/2 controls cancer cell growth and tumorigenesis via distinct regulation of cell cycle progression, cytokinesis, and tetraploidy

Figure 4

Regulation of cell cycle progression and cell cycle-associated proteins by Aur A/B and BRCA1/2. A-B, Cell cycle distributions detected by flow cytometry before or after silencing of Aur A/B and/or BRCA1/2. C-D, Alteration of cell cycle regulatory proteins tested by immunoblotting. Inverse regulation of p53 and cyclin A by Aur A/B and BRCA1/2 in both Capan-1 and OVCA433 cells is conceived. β-actin is used as a loading control.

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