Molecular Cancer

Table 1 Changes in tumor microvasculature during multistep carcinogenesis

From: Vasohibin-2 modulates tumor onset in the gastrointestinal tract by normalizing tumor angiogenesis

		Apc mice
Adenoma-carcinoma sequence:	Normal tissue	Adenoma	Adenoma	Adeno Ca
Adenoma-carcinoma sequence:	Normal tissue	(early)	(late)	Adeno Ca
Morphological abnormality;
Vessel density	-	1+	2+	3+
Lumen	Round	Not round	Not round	Not round
	Systematic	Tortuous	Tortuous	Tortuous
Branching	-	1+	2+	3+
Irregularity	-	2+	3+	3+
Ec
Morphology	Normal	Protuberance	Protuberance	Protuberance
		Microvilli	Microvilli	Microvilli
IHC Lectin	+	+	+	+
CD31	+	+	+	+
CD105	-	±	+	+
BM
Morphology	Single	Multiple	Multiple	Multiple
Pc
Morphology	Attached	Detached	Detached	Detached
		Protuberance	Protuberance	Protuberance
IHC Desmin	+	+	+	+
α-SMA	-	-	±	+
Pv
IHC VASH2	-	-	+	+
Functional abnormality;
Permeability	-	-	+	++
Blood flow (lectin)	Normal	Irregularity 1+	Irregularity 2+	Irregularity 2+
Hypoxia (HIF1-α)	-	-	±	+
Gene mutation	Apc	Apc	K-ras	p53 and more
Stage of microvasculature	Stage 0	Stage I	Stage IIa	Stage IIb

Apc: Apc^Min/+, Ec: Endothelial cell, BM: Basement membrane, Pc: Pericyte, Pv: Peripheral tumor vessel, IHC: Immunohistochemistry. Samples were scored as negative (-), mild (1+), Moderate (2+), Severe (3+). Positive staining was recorded as absent (-), weak (±), positive (+), strong (++).

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ISSN: 1476-4598

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