TY - JOUR AU - Kodet, Ondřej AU - Lacina, Lukáš AU - Krejčí, Eliška AU - Dvořánková, Barbora AU - Grim, Miloš AU - Štork, Jiří AU - Kodetová, Daniela AU - Vlček, Čestmír AU - Šáchová, Jana AU - Kolář, Michal AU - Strnad, Hynek AU - Smetana, Karel PY - 2015 DA - 2015/01/05 TI - Melanoma cells influence the differentiation pattern of human epidermal keratinocytes JO - Molecular Cancer SP - 1 VL - 14 IS - 1 AB - Nodular melanoma is one of the most life threatening tumors with still poor therapeutic outcome. Similarly to other tumors, permissive microenvironment is essential for melanoma progression. Features of this microenvironment are arising from molecular crosstalk between the melanoma cells (MC) and the surrounding cell populations in the context of skin tissue. Here, we study the effect of melanoma cells on human primary keratinocytes (HPK). Presence of MC is as an important modulator of the tumor microenvironment and we compare it to the effect of nonmalignant lowly differentiated cells also originating from neural crest (NCSC). SN - 1476-4598 UR - https://doi.org/10.1186/1476-4598-14-1 DO - 10.1186/1476-4598-14-1 ID - Kodet2015 ER -