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Figure 1 | Molecular Cancer

Figure 1

From: Melanoma cells influence the differentiation pattern of human epidermal keratinocytes

Figure 1

Detection of keratin 14 (K14, A-D, F), protein S100 (B), keratin 10 (K10, E, G), and Ki67 (H, I). K14 is expressed only in basal layer in normal epidermis (A). In junctional naevi, the S100 positive naevus cells (green signal, marked by asterisk) are surrounded by K14 positive basal and suprabasal keratinocytes (B). Epidermis surrounding nodular melanoma reveals pseudoepitheliomatous hyperplasia with high expression of K14 (C), however, proliferation marker Ki67 is negative here (H). At the margin of surgical resecate (MSR) is K14 expressed in all suprabasal layers (D), this aberrant expression is accompanied by loss of differentiation marker K10 (E) and high proliferation revealed by the presence of Ki67 (I). Similarly, epidermis overlaying dermal metastasis of melanoma is K14 positive even suprabasally (F); expression of K10 is dislocated more superficially (G). The epithelium in melanoma resecates reaches its thickest point on the periphery of the tumor margin (J). The tumor center is covered by the epithelium of variable thickness (J). Scale bars denote 25 μm.

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