Table 1 Signal molecules activated or upregulated by COX and LOX metabolites
Metaboltes | Activated Molecules | References |
|---|---|---|
13-HODE | PKCα | Liu et al, 1995 |
12-HETE | PKCα | Liu et al, 1997 |
12-HETE | c-Src | Szekeres et al, 2000 |
12-HETE | PI3 kinase | Szekeres et al, 2000 |
5-HETE | PI3 kinase | Ding et al, 2001 |
5-HETE | tyrosine kinase | Ding et al, 2001 |
5-HETE/12-HETE | P38 kinase | Ding et al, 2001 |
PGE2 | VEGF | Pai et al, 2001 |
12-HETE | ERK1/2 | Ding et al, 2001 |
PGE2/EP3 receptor | Ras/MEK/ERK | Yano et al, 2002 |
PGE2 | EGF receptor | Pai et al, 2002 |
PGE2/EP4 | IL-6 release | Fiebich et al, 2001 |
PGE2/EP2/EP4 | PI3 kinase/GSK | Fujino et al, 2002 |
PGE2 | STAT | Liu et al, 2002 |
LTB4 | ERK1/2 | Tong et al, 2002 |