| Methylated genes | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Parameter | Overall | CDH1 | DAPK | RARB | HIC1 | FHIT | RASSF1A | APC | CDKN2A | MGMT | BRCA1 |
Histology | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   SCC (N = 77) | 66 | 45 | 36 | 24 | 12 | 9 | 5 | 5 | 6 | 4 | 3 |
   AC (N = 5) | 5 | 0 | 1 | 0 | 3 | 0 | 1 | 4 | 1 | 0 | 2 |
Significance | P = 1.00 | P = 0.02 | P = 0.372 | P = 0.315 | P = 0.040 | P = 1.00 | P = 0.323 | P = 0.0003 | P = 0.367 | P = 1.00 | P = 0.028 |
Stage | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   I (N = 17) | 10 | 6 | 5 | 3 | 5 | 0 | 4 | 2 | 2 | 0 | 0 |
   II (N = 19) | 19 | 13 | 12 | 5 | 3 | 3 | 2 | 2 | 1 | 0 | 2 |
   III-IV (N = 46) | 42 | 16 | 20 | 16 | 7 | 6 | 0 | 5 | 4 | 4 | 3 |
Significance | P = 0.0005 | P = 0.0005 | P = 0.129 | P = 0.394 | P = 0.460 | P = 0.279 | P = 0.003 | P = 1.00 | P = 0.759 | P = 0.395 | P = 0.397 |
Size of tumor | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   1–5 cm (N = 32) | 28 | 20 | 13 | 10 | 8 | 3 | 4 | 4 | 1 | 0 | 1 |
   ≥ 6 cm (N = 38) | 34 | 21 | 19 | 13 | 6 | 4 | 1 | 3 | 4 | 2 | 2 |
Significance | P = 1.000 | P = 0.540 | P = 0.433 | P = 0.793 | P = 0.337 | P = 1.00 | P = 0.171 | P = 0.695 | P = 0.366 | P = 0.497 | P = 1.000 |
Age (yrs) | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   ≤ 40 (N = 32) | 28 | 17 | 17 | 12 | 6 | 6 | 1 | 1 | 3 | 3 | 1 |
   41–50 (N = 17) | 12 | 8 | 5 | 5 | 3 | 0 | 2 | 0 | 1 | 1 | 1 |
   51–60 (N = 13) | 13 | 6 | 5 | 6 | 3 | 2 | 1 | 6 | 1 | 0 | 3 |
   > 60 (N = 20) | 18 | 14 | 10 | 1 | 3 | 1 | 2 | 2 | 2 | 0 | 0 |
Significance | P = 0.113 | P = 0.439 | P = 0.400 | P = 0.021 | P = 0.956 | P = 0.169 | P = 0.600 | P = 0.0004 | P = 1.000 | P = 0.467 | P = 0.053 |
Clinical Outcome | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Alive (N= 39) | 30 | 18 | 19 | 8 | 7 | 3 | 5 | 4 | 2 | 0 | 0 |
DOC (N= 43) | 41 | 27 | 18 | 16 | 8 | 6 | 1 | 5 | 5 | 4 | 5 |
Significance | 0.015 | P = 0.131 | P = 0.533 | P = 0.097 | P = 0.939 | P = 0.487 | P = 0.097 | P = 1.000 | P = 0.436 | P = 0.118 | P = 0.056 |
Treatment response¶ |  |  |  |  |  |  |  |  |  |  |  |
CR (N= 21) | 19 | 11 | 15 | 3 | 4 | 1 | 2 | 3 | 2 | 0 | 0 |
DOC/PR (N = 26) | 24 | 15 | 10 | 12 | 4 | 3 | 1 | 4 | 3 | 2 | 2 |
Significance | 1.000 | 0.716 | 0.024 | 0.020 | 1.000 | 0.617 | 0.579 | 1.000 | 1.000 | 0.495 | 0.495 |
HPV type | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   HPV 16 (N = 47) | 42 | 27 | 24 | 15 | 9 | 6 | 4 | 5 | 3 | 3 | 2 |
   HPV 18 (N = 6) | 5 | 2 | 1 | 1 | 2 | 0 | 1 | 1 | 1 | 0 | 1 |
   Multiple (N = 11) | 8 | 7 | 3 | 2 | 1 | 0 | 0 | 2 | 2 | 0 | 1 |
   Others (N = 16) | 12 | 9 | 8 | 5 | 2 | 3 | 0 | 0 | 1 | 1 | 1 |
significance | P = 0.543 | P = 0.740 | P = 0.280 | P = 0.792 | P = 0.560 | P = 0.467 | P = 0.365 | P = 0.288 | P = 0.327 | P = 1.000 | P = 0.412 |
MSI | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   MSS (N = 30) | 26 | 20 | 17 | 4 | 2 | 3 | 1 | 2 | 5 | 4 | 2 |
   MSI-L (N = 9) | 9 | 6 | 4 | 2 | 1 | 2 | 1 | 0 | 1 | 0 | 2 |
   MSI-H (N = 9) | 8 | 2 | 3 | 3 | 4 | 0 | 1 | 3 | 1 | 0 | 1 |
Significance | P = 0.516 | P = 0.065 | P = 0.513 | P = 0.434 | P = 0.023 | P = 1.000 | P = 0.313 | P = 0.079 | P = 1.000 | P = 0.443 | P = 0.266 |