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Table 2 Correlation of promoter methylation with clinical and histologic parametrs, HPV status and microsatellite instability in CC patients

From: Frequent Promoter Methylation of CDH1, DAPK, RARB, and HIC1 Genes in Carcinoma of Cervix Uteri: Its Relationship to Clinical Outcome

  Methylated genes
Parameter Overall CDH1 DAPK RARB HIC1 FHIT RASSF1A APC CDKN2A MGMT BRCA1
Histology            
   SCC (N = 77) 66 45 36 24 12 9 5 5 6 4 3
   AC (N = 5) 5 0 1 0 3 0 1 4 1 0 2
Significance P = 1.00 P = 0.02 P = 0.372 P = 0.315 P = 0.040 P = 1.00 P = 0.323 P = 0.0003 P = 0.367 P = 1.00 P = 0.028
Stage            
   I (N = 17) 10 6 5 3 5 0 4 2 2 0 0
   II (N = 19) 19 13 12 5 3 3 2 2 1 0 2
   III-IV (N = 46) 42 16 20 16 7 6 0 5 4 4 3
Significance P = 0.0005 P = 0.0005 P = 0.129 P = 0.394 P = 0.460 P = 0.279 P = 0.003 P = 1.00 P = 0.759 P = 0.395 P = 0.397
Size of tumor            
   1–5 cm (N = 32) 28 20 13 10 8 3 4 4 1 0 1
   ≥ 6 cm (N = 38) 34 21 19 13 6 4 1 3 4 2 2
Significance P = 1.000 P = 0.540 P = 0.433 P = 0.793 P = 0.337 P = 1.00 P = 0.171 P = 0.695 P = 0.366 P = 0.497 P = 1.000
Age (yrs)            
   ≤ 40 (N = 32) 28 17 17 12 6 6 1 1 3 3 1
   41–50 (N = 17) 12 8 5 5 3 0 2 0 1 1 1
   51–60 (N = 13) 13 6 5 6 3 2 1 6 1 0 3
   > 60 (N = 20) 18 14 10 1 3 1 2 2 2 0 0
Significance P = 0.113 P = 0.439 P = 0.400 P = 0.021 P = 0.956 P = 0.169 P = 0.600 P = 0.0004 P = 1.000 P = 0.467 P = 0.053
Clinical Outcome            
Alive (N= 39) 30 18 19 8 7 3 5 4 2 0 0
DOC (N= 43) 41 27 18 16 8 6 1 5 5 4 5
Significance 0.015 P = 0.131 P = 0.533 P = 0.097 P = 0.939 P = 0.487 P = 0.097 P = 1.000 P = 0.436 P = 0.118 P = 0.056
Treatment response¶            
CR (N= 21) 19 11 15 3 4 1 2 3 2 0 0
DOC/PR (N = 26) 24 15 10 12 4 3 1 4 3 2 2
Significance 1.000 0.716 0.024 0.020 1.000 0.617 0.579 1.000 1.000 0.495 0.495
HPV type            
   HPV 16 (N = 47) 42 27 24 15 9 6 4 5 3 3 2
   HPV 18 (N = 6) 5 2 1 1 2 0 1 1 1 0 1
   Multiple (N = 11) 8 7 3 2 1 0 0 2 2 0 1
   Others (N = 16) 12 9 8 5 2 3 0 0 1 1 1
significance P = 0.543 P = 0.740 P = 0.280 P = 0.792 P = 0.560 P = 0.467 P = 0.365 P = 0.288 P = 0.327 P = 1.000 P = 0.412
MSI            
   MSS (N = 30) 26 20 17 4 2 3 1 2 5 4 2
   MSI-L (N = 9) 9 6 4 2 1 2 1 0 1 0 2
   MSI-H (N = 9) 8 2 3 3 4 0 1 3 1 0 1
Significance P = 0.516 P = 0.065 P = 0.513 P = 0.434 P = 0.023 P = 1.000 P = 0.313 P = 0.079 P = 1.000 P = 0.443 P = 0.266
  1. P value corresponds to the P value from the Fisher's Exact test for the first two rows and for the P value from the Analysis of Variance for the last 3 rows. ¶Only patients with at least 5 months follow-up and treatment were considered and patients with treatment unknown or no treatment were excluded. SCC, squamous cell carcinoma; AC, adenocarcinoma; MSS, microsatellite stable; MSI-L, microsatellite instability low; MSI-H, microsatellite instability high; DOC, died of cancer; PR, partial response