Table 1 SMAD4 status and TGFβ1 response of selected tumor cell lines were: (1) confirmed by PCR sequencing (data not shown) and (2) by [3H] thymidine incorporation assays (data not shown). WT denotes wild type.
Cell lines | Smad4 status1 | Growth inhibition2 by TGFβ1 |
|---|---|---|
Panc-1 | + (WT) | + |
BxPC-3 | - (homozygous deleted) | + |
Capan-1 | - (frame shift mutation) | - |
AsPC-1 | - (amino acid replacement) | - |
HeLa | + (WT) | + |
MCF-7 | + (WT) | + |
MDA-MB-231 | + (WT) | + |