Figure 3

Proteins that physically interact with Ets1. Proteins that cooperate with Ets1 to activate genes are shown in light yellow, proteins that either repress Ets1 activity or cooperate with Ets1 to repress gene activity are shown in pink. Proteins whose specific sites of interaction on the Ets1 protein are not yet defined (Sp1, HTLV-I Tax, mut p53) are indicated below. AML1 = acute-myeloid-leukemia-1, AP-1 = activator protein 1, ATF2 = activating transcription factor 2, CBP = CREB binding protein, ERK1/2 = extracellular-signal-regulated kinase 1/2, HIF-2α = hypoxia-inducible factor 2α, HTLV-I Tax = human T-cell lymphotropic virus-I transactivating protein of region X, MafB = musculoaponeurotic fibrosarcoma B, NFAT = nuclear factor of activated T-cells, Pax5 = paired box containing gene 5, Pit-1 = pituitary-specific trans-acting factor 1, Sp100 = speckled, 100 kD, Stat5 = signal transducer and activators of transcription 5, EAP = Ets1-associated protein, UBC9 = ubiquitin-conjugating enzyme 9, USF-1 = upstream stimulatory factor 1, VDR = vitamin D receptor