Figure 5

Factors that modulate Ets1 expression. Transcription factors that directly bind to the Ets1 promoter are shown in light yellow, kinases are in orange, growth factors and other factors are in green. AP-1 = activator protein 1, ERK1/2 = extracellular-signal-regulated kinase 1/2, HGF = hepatocyte growth factor, HIF-1 = hypoxia-inducible factor 1, PDGF = platelet derived growth factor, PKC = protein kinase C, RA = retinoic acid, RAR = retinoic acid receptor, TNFα = tumor necrosis factor α, wt p53 = wildtype p53.