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Table 2 Ets1 expression in tumors

From: The Biology of the Ets1 Proto-Oncogene

tumor of

cancer type

tumoral expression

stromal(S)/vascular (V) expression

comments

reference

brain

astrocytoma

0% (grade II), 25% (III), 65% (IV)

high expression in glioma microvasculature

higher expression in recurrent vs. primary tumors;

[23, 91, 133]

 

meningioma

benign (38%), invasive (86%)

 

invasive tumor: correlation with uPA expression

[134]

breast

invasive carcinoma, DCIS, LCIS invasive cell lines

62%

correlates with VEGF, MMP1 and MMP9 expression

prognostic marker for poor prognosis

[74, 97, 128, 135, 136]

cartilage/bone (jaw)

chondro-sarcoma

60%

  

[137]

 

osteosarcoma

0%

   

cervix

cervical carcinoma

 

correlates with TMD

correlates with poor prognosis

[127]

colon/rectum

adenomas

0–44%

  

[126, 138, 139]

 

colon cancer

48–84%

65% (V) correlates with TMD, 28% (S) correlated with lung metastasis

vascular Ets1: linked with LNM and poor prognosis

 

endometrium

endometrial carcinoma

 

correlates with TMD

associates with histological grade, detected in cytoplasm

[24, 125]

esophagus

squamous carcinoma

 

correlates with VEGF

heterogenous expression, higher at invasive sites

[140, 141]

liver/biliary tract

hepatocellular carcinoma

50–100%

 

higher in poorly differentiated tumors

[142]

 

bile duct carcinoma

61%

 

higher in well-differentiated tumors

[143]

 

cholangio-cellular carcinomas

22%

   

lung

pulmonary adeno-carcinoma

  

linked to LNM

[130, 144]

lymphoid tissue

T-leukemic cells (T-ALL, ATL)

   

[132]

mouth

squamous cell carcinoma

58%

 

correlates with tumor stage and LNM

[131]

ovary

benign cystadenoma

0%

  

[25, 129, 145]

 

carcinoma

42%, higher when stroma is invaded

33% (S), correlates with MMP1 and MMP9 expression

associated with poor prognosis

 

pankreas

adeno-carcinoma

81%

 

lower in poorly differentiated carcinoma

[146]

stomach

adenomas

0%

  

[147, 148]

 

adeno-carcinoma

64%

correlates with TMD

  
 

mucosal carcinoma

12%

   

thymus

thymoma

  

higher in higher grade tumors

[149]

thyroid gland

thyroid carcinoma

40% (adenomas), 50–98% (carcinoma)

  

[150]

vascular system (skin)

haemangioma

weak

  

[151]

 

granuloma pyogenicum

weak

   
 

angiosarcoma

strong expression

 

correlates with MMP1 expression

 
  1. TMD = tumor microvessel density, LNM = lymph node metastasis, DCIS = ductal carcinoma in situ, LCIS = lobular carcinoma in situ