Figure 3

Effect of STI571 on growth factor-induced cell proliferation. Mia-PaCa-2 and T3M4 cells were cultured in 1% FCS medium and incubated in the absence (solid circle) or presence (open triangle) of STI571 (at GI₅₀ concentration for each cell line) and increasing concentrations of the indicated growth factors for 72 hours. Cell growth was determined by the MTT assay. Percent growth inhibition was calculated by comparison with control cell growth. Values shown are the mean ± SEM obtained from three independent experiments.