Table 1 GI₅₀ concentration of STI571 in different cancer cell lines in comparison to STI571 plasma concentrations. ^# as determined in complete medium.

Aspc-1^#

31.5

BxPc-3^#

21

Capan-1^#

19

Colo-357^#

17

Mia-PaCa-2^#

26

T3M4^#

25

lung cancer (6 cell lines) [16]

~5

lung cancer (A549 cell line) [32]

2–3

colorectal cancer (HT29) [34]

6

CML (K562 cell lines) [35]

0.56

STI571 plasma levels[19]

0.17–5.68