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Figure 2 | Molecular Cancer

Figure 2

From: Role of APC and DNA mismatch repair genes in the development of colorectal cancers

Figure 2

Structural features of the APC protein. Most of the mutations in APC occur in the mutator cluster region (MCR) and create truncated proteins. The truncated proteins contain ASEF and β-catenin binding sites in the armadillo-repeat domain but looses the β-catenin regulatory activity which is located in the 20-amino acids repeat domain. Somatic mutations are selected more frequently in FAP patients with germ-line mutations outside of the MCR.

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