Figure 2
From: Role of APC and DNA mismatch repair genes in the development of colorectal cancers
Structural features of the APC protein. Most of the mutations in APC occur in the mutator cluster region (MCR) and create truncated proteins. The truncated proteins contain ASEF and β-catenin binding sites in the armadillo-repeat domain but looses the β-catenin regulatory activity which is located in the 20-amino acids repeat domain. Somatic mutations are selected more frequently in FAP patients with germ-line mutations outside of the MCR.