Figure 5
From: Role of APC and DNA mismatch repair genes in the development of colorectal cancers
Chromosomal instability (CIN) in cells carrying mutations in APC gene. Panel A shows a model for the interaction of APC with plus-end of microtubule through EB1 and with kinetochore of chromosome through Bub1 in normal colonic epithelial cells. APC can also bind microtubules directly via the C-terminal basic domain. Panel B shows a disruption in the interaction between spindle microtubules and kinetochores due to expression of truncated form of APC in colon cancer cells.