Table 1 Examples of Angiogenic Growth Factors that Are Overexpressed in Human Pancreatic Cancer and their Cognate Receptors
From: Pathways for aberrant angiogenesis in pancreatic cancer
Growth Factors Activating Tyrosine Kinase Receptors | Receptor |
|---|---|
VEGF-A | VEGFR-1 and VEGFR-2 |
VEGF-C | VEGFR-3 |
EGF, TGF-α, HB-EGF | EGF receptor |
FGF-1, -2, -5 | FGF receptors, types 1 and 2 |
PDGF B chain | PDGF receptors α and β |
IGF-1 | IGF-1 receptor |
Hepatocyte growth factor | MET |
Growth Factors that Activate Serine-Threonine Kinase Receptors | Â |
TGF-β1, -2, -3 | Type II TGF-β receptor |
Pro-Angiogenic Chemokines | Â |
IL-8 | CXCR1 and CXCR2 |
Mip 3α | CCR6 |