Sequence alignment of the DH and PH domains (A) DH domains. Residues 1085–1253 of Scambio (Sabi) were aligned with similar sequences of Dbl, Trio and Dbs. (B) PH domains. The PH domains of Dbl, Trio, and Dbs were aligned with residues 1265–1372 of Scambio (Sabi). Conserved amino acid residues are blue (identical residues in some aligned sequences, but not all), green (conservative substitutions) or red (identical residues in all aligned sequences). Non-homologous residues are shown in black.