Skip to main content

Table 2 Examples of some of the regulatory pathways affected by 5-FU exposure, and associated genes that were scored as up- or down-regulated in one or more HCT116 treatment-derivatives.

From: Comparison of gene expression in HCT116 treatment derivatives generated by two different 5-fluorouracil exposure protocols

Regulatory pathway affected Altered gene in one or more derivatives Bolus3 signal log2 ratio ContinB signal log2 ratio ContinD signal log2 ratio
5-FU-metabolism DHFR 0.6 0.7 1.0
  DPYD -1.0 -1.5 -0.9
  DTYMK 1.0 1.4 0.7
  TYMS 0.7 0.9 0.7
  UP 1.2 1.6 (0.3)
Apoptosis ANXA4 -1.0 -1.2 (-0.3)
  BIRC5 0.6 1.2 0.7
  BNIP3L -2.4 -2.7 -0.5
  IRAK1 1.4 1.6 0.6
  MALT1 0.6 1.5 0.8
  PDCD4 -2.8 -2.9 (0.0)
DNA repair FANCG 2.1 2.3 1.7
  FEN1 1.5 1.7 1.1
  RAD23B 2.3 2.3 (0.2)
  1. Signal log2 ratios ≥ 0.5 defined an up-regulated gene, and signal log2 ratios ≤ -0.5 defined a down-regulated gene. Values in parentheses represent 'no change' scores and are included here for comparison.